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  1. Article

    Open Access

    piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis

    The intermitochondrial cement (IMC) and chromatoid body (CB) are posited as central sites for piRNA activity in mice, with MIWI initially assembling in the IMC for piRNA processing before translocating to the ...

    Huan Wei, Jie Gao, Di-Hang Lin, Ruirong Geng, Jiaoyang Liao… in Nature Communications (2024)

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  2. No Access

    Article

    The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility

    PIWI-clade proteins harness piRNAs of 24–33 nt in length. Of great puzzles are how PIWI-clade proteins incorporate piRNAs of different sizes and whether the size matters to PIWI/piRNA function. Here we report ...

    **n Wang, Di-Hang Lin, Yue Yan, An-Hui Wang, Jiaoyang Liao… in Science China Life Sciences (2023)

  3. No Access

    Article

    piRNA 3′ uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells

    Mao-Zhou Zhao, Di-Hang Lin, Heng Zuo, Huan Wei, **n Wang, Lan-Tao Gou… in Cell Research (2022)