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  1. No Access

    Article

    VCP Inhibition Augments NLRP3 Inflammasome Activation

    Lysosomal membrane permeabilization caused either via phagocytosis of particulates or the uptake of protein aggregates can trigger the activation of NLRP3 inflammasome- an intense inflammatory response that dr...

    Ankita Sharma, Dhruva D. Dhavale, Paul T. Kotzbauer, Conrad C. Weihl in Inflammation (2024)

  2. Article

    Open Access

    Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

    The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation of alpha-synuclein (Asyn) fibrils in Lewy bodies and Lewy neurites. Here we develop and validate a method to ampl...

    Dhruva D. Dhavale, Alexander M. Barclay, Collin G. Borcik… in Nature Communications (2024)

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  3. No Access

    Article

    13C and 15N resonance assignments of alpha synuclein fibrils amplified from Lewy Body Dementia tissue

    Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-sta...

    Alexander M. Barclay, Dhruva D. Dhavale, Collin G. Borcik… in Biomolecular NMR Assignments (2023)

  4. No Access

    Article

    Resonance assignments of an α-synuclein fibril prepared in Tris buffer at moderate ionic strength

    Fibrils of the protein α-synuclein (α-syn) are implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders. We have reported a high-resolution structure (PDB 2N0A) of an α-syn...

    Alexander M. Barclay, Dhruva D. Dhavale, Joseph M. Courtney… in Biomolecular NMR Assignments (2018)

  5. Article

    Open Access

    Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer’s Disease

    Fluselenamyl (5), a novel planar benzoselenazole shows traits desirable of enabling noninvasive imaging of Aβ pathophysiology in vivo; labeling of both diffuse (an earlier manifestation of neuritic plaques) and f...

    G. S. M. Sundaram, Dhruva D. Dhavale, Julie L. Prior, ** Yan… in Scientific Reports (2016)

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