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Open AccessThe proinflammatory cytokines IL-1β and TNF-α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway
The overgrowth of synovial tissues is critical in the pathogenesis of rheumatoid arthritis (RA). The expression of Synoviolin (SYN), an E3 ubiquitin ligase, is upregulated in arthritic synovial fibroblasts and...
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Article
Open AccessClinical correlates of health-related quality of life among opioid-dependent patients
Previous work suggests that opioid users have lower health-related quality of life (HRQOL) than patients with more prevalent chronic illnesses such as hypertension or diabetes. Although comparisons with popula...
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Article
Open AccessInfluence of degree of specific allergic sensitivity on severity of rhinitis and asthma in Chinese allergic patients
The association between sensitizations and severity of allergic diseases is controversial.
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Open AccessSeroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China
Porcine proliferative enteropathy caused by Lawsonia intracellularis (L. intracellularis) is a major concern to the pig industry worldwide. Although 8.3 billion pigs are produced each year in China, few reports o...
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HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone Acetylation
Antipsychotic drugs are widely prescribed to elderly patients for the treatment of a variety of psychopathological conditions, including psychosis and the behavioral disturbances associated with dementia. Howe...
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Open AccessCortical functional activity in patients with generalized anxiety disorder
The neurological correlates of Generalised Anxiety Disorder (GAD) are not well known, however there is evidence of cortical dysregulation in patients with GAD. The aim of the study was to examine cortical func...
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RETRACTED ARTICLE: Interleukin-33 promotes helper T cell type-2/17 inflammation in children with allergic rhinitis
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Open AccessAdult pancreatic cavernous hemangioma: case presentation of a benign tumor with a complex composition
Pancreatic cavernous hemangioma is an extremely rare benign tumor that is difficult to diagnose on an imaging examination, and its histopathological examination has rarely been reported.
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Article
Open AccessA middle-aged male patient with de Winter syndrome: a case report
De Winter syndrome accounts for approximately 2% of all patients with acute anterior myocardial infarction admitted to the emergency department, and is characterized by severe stenosis of the left anterior des...
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Open AccessClinical significance of D-dimer levels in refractory Mycoplasma pneumoniae pneumonia
The levels of serum D-dimer (D-D) in children with Mycoplasma pneumoniae pneumonia (MPP) were assessed to explore the clinical significance of D-D levels in refractory MPP (RMPP).
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Open AccessmiR-122-5p regulates the tight junction of the blood-testis barrier of mice via occludin
Occludin protein is the primary assembling protein of TJs and the structural basis for tight junction formation between Sertoli cells in the spermatogenic epithelium. The expression of miR-122-5p and occludin ...
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Open AccessCharacterization of gut microbiome in mice model of depression with divergent response to escitalopram treatment
Depression is a common and heterogeneous mental disorder. Although several antidepressants are available to treat the patients with depression, the factors which could affect and predict the treatment response...
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Open AccessSuccess of small-dose fractionated sodium thiosulfate in the treatment of calciphylaxis in a peritoneal dialysis patient
Calciphylaxis, or calcific uremic arteriolopathy (CUA), is a rare, fatal disorder of microvascular calcification and thrombosis that typically affects patients with end-stage renal disease (ESRD) receiving lon...
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Open AccessLaparoscopic versus open reduction of idiopathic intussusception in children: an updated institutional experience
In the reduction of intussusception, due to the lack of randomized, controlled, and prospective clinical trials to confirm the superiority of the laparoscopic approach over open surgery, more evidence was need...
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Open AccessAptamer blocking S-TLR4 interaction selectively inhibits SARS-CoV-2 induced inflammation
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Open AccessAcetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development
Acetyl-CoA synthetase 2 (ACSS2), an important member of the acetyl-CoA synthetase (ACSS) family, can catalyze the conversion of acetate to acetyl coenzyme A (acetyl-CoA). Currently, acetyl-CoA is considered an...
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Article
Open AccessPredominantly epithelial-type synovial sarcoma with overwhelming neuroendocrine differentiation: a potential diagnostic pitfall
Synovial sarcoma is an uncommon soft tissue tumor of soft tissue, characterized by a specific SS18 rearrangement. It generally manifests as a lesion composed of monomorphic spindle cells and sometimes shows va...
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Open AccessAn updated RBD-Fc fusion vaccine booster increases neutralization of SARS-CoV-2 Omicron variants
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Open AccessChimeric antigen receptor T-cell therapy for relapsed and refractory thyroid cancer
The prognosis of most thyroid cancer patients is excellent, but for those with advanced or metastatic thyroid cancer, effective treatments are still lacking. Chimeric antigen receptor (CAR) T-cell therapy has ...
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Open AccessComparison of the duration of viral RNA shedding and anti-SARS-CoV-2 spike IgG and IgM antibody titers in COVID-19 patients who were vaccinated with inactivated vaccines or not: a retrospective study
At present, the role of inactivated vaccines in viral RNA shedding among Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) breakthrough infections is still unknown.