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Open AccessProposal and validation of a new approach in tele-rehabilitation with 3D human posture estimation: a randomized controlled trial in older individuals with sarcopenia
Through a randomized controlled trial on older adults with sarcopenia, this study compared the training effects of an AI-based remote training group using deep learning-based 3D human pose estimation technolog...
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Open AccessExperimental verification about treatment of Bu-Shen-Yi-**g-Fang in Alzheimer’s disease by the analysis of the feasible signaling pathway of network pharmacology
Bu-shen-yi-**g-fang (BSYJF) has been reported to reduce amyloid-β (Aβ)1–42 deposition in the brain of APP/PS1 mice and ameliorate cognitive function. However, its neuroprotective mechanism remains unclear.
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Article
Open AccessAn immune-related adverse event of Behcet’s-like syndrome following pembrolizumab treatment
In recent years, the emergence of immunotherapy has renewed therapeutic modality. Different from traditional anti-tumor therapy, immune-related adverse events of skin, gastrointestinal tract, liver, lung, endo...
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Article
Open AccessInforming immunotherapy with multi-omics driven machine learning
Progress in sequencing technologies and clinical experiments has revolutionized immunotherapy on solid and hematologic malignancies. However, the benefits of immunotherapy are limited to specific patient subse...
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Article
Open AccessRituximab may affect T lymphocyte subsets balance in primary membranous nephropathy
The aim of this study was to investigate the effects and significance of rituximab (RTX) on the levels of T lymphocyte subsets in patients diagnosed with primary membranous nephropathy (PMN).
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Article
Open AccessCorrection: Prediction of the SF-6D utility score from lung cancer FACT-L: a map** study in China
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Open AccessIntegrative study of pulmonary microbiome, transcriptome and clinical outcomes in Mycoplasma pneumoniae pneumonia
This study aimed to investigate the interactions among three core elements of respiratory infection—pathogen, lung microbiome, and host response—and their avocation with the severity and outcomes of Mycoplasma pn...
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Article
Open AccessPrediction of the SF-6D utility score from Lung cancer FACT-L: a map** study in China
To develop a map** algorithm for generating the Short Form Six-Dimension (SF-6D) utility score based on the Functional Assessment of Cancer Therapy-Lung (FACT-L) of lung cancer patients.
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Open AccessThymic hyperplasia with lymphoepithelial sialadenitis (LESA)-like features: a case report and literature review
Thymic hyperplasia with lymphoepithelial sialadenitis-like features (LESA-like TH) is a rare form of thymic hyperplasia, characterized by a prominent expansion of the thymic medulla containing hyperplastic lym...
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Open AccessBody landmarks and genetic algorithm-based approach for non-contact detection of head forward posture among Chinese adolescents: revitalizing machine learning in medicine
Addressing the current complexities, costs, and adherence issues in the detection of forward head posture (FHP), our study conducted an exhaustive epidemiologic investigation, incorporating a comprehensive pos...
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Article
Open AccessHeavy metals in drinking water and periodontitis: evidence from the national oral health survey from China
Periodontitis has become an increasingly important public health issue, coupled with a high economic burden for prevention and treatment. Exposure to essential trace heavy metals has been associated with vario...
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Article
Open AccessCharacterizing the penumbras of white matter hyperintensities in patients with cerebral small vessel disease
The white matter hyperintensity penumbra (WMH-P) is the subtly changed normal-appearing white matter (NAWM) that surrounds white matter hyperintensities (WMHs). The goal of this study was to define WMH-P in ce...
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Open AccessExamining racial disparity in psychotic disorders related ambulatory care visits: an observational study using national ambulatory medical care survey 2010–2015
One of the most consistent research findings related to race and mental health diseases is the disproportionately high rate of psychotic disorder diagnoses among people of color, specifically people of African...
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Open AccessGastrointestinal symptoms of long COVID-19 related to the ectopic colonization of specific bacteria that move between the upper and lower alimentary tract and alterations in serum metabolites
Since the coronavirus disease 2019 (COVID-19) outbreak, many COVID-19 variants have emerged, causing several waves of pandemics and many infections. Long COVID-19, or long-term sequelae after recovery from COV...
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Open AccessSignificance of ypTNM stage in determining the prognosis and therapy after surgery for locally advanced rectal cancer
In the current NCCN guidelines, the prognosis and adjuvant chemotherapy of patients who underwent neoadjuvant chemoradiotherapy (nCRT) are based on pre-radiotherapy clinical TNM (cTNM) stage. However, the valu...
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Open AccessEosinophilic solid and cystic renal cell carcinoma with TSC2 mutation: a case report and literature review
Eosinophilic solid and cystic renal cell carcinoma (ESC-RCC) is an under-recognized, emerging new entity of sporadic renal neoplasms, which is listed as a rare type of renal cell carcinoma in the 2022 WHO rena...
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Article
Open AccessAcinar cell carcinoma of gastric ectopic pancreas origin: a case report and literature review
Primary pancreatic-type acinar cell carcinoma of the stomach is extremely rare, often misdiagnosed, and of unclear origin.
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Article
Open AccessNeuroendocrine differentiation: a risk fellow in colorectal cancer
Neuroendocrine differentiation (NED) is often found in colorectal cancer (CRC) and may have unique biological behavior, which has not been previously delineated. Here, we explore the relationship between CRC, ...
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Article
Open AccessDlk1 maintains adult mice long-term HSCs by activating Notch signaling to restrict mitochondrial metabolism
Adult hematopoietic stem cells (HSCs) homeostasis is critically important in maintaining lifelong hematopoiesis. However, how adult HSCs orchestrate its homeostasis remains not fully understood. Imprinted gene...
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Open AccessSinonasal mucosal melanoma with smooth muscle differentiation: a potential pathological diagnostic pitfall
Sinonasal mucosal melanoma (SNMM) is a rare malignant melanoma originating from melanocytes derived from multipotent neural crest cells. Its incidence accounts for less than 1 % of all malignant melanomas, wit...