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  1. Article

    Open Access

    Molecular and epigenetic regulatory mechanisms of normal stem cell radiosensitivity

    Ionizing radiation (IR) therapy is a major cancer treatment modality and an indispensable auxiliary treatment for primary and metastatic cancers, but invariably results in debilitating organ dysfunctions. IR-i...

    Maria Rita Fabbrizi, Kacie E. Warshowsky, Cheri L. Zobel… in Cell Death Discovery (2018)

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  2. Article

    Open Access

    Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy

    Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging. Stem cells exhibit attenuated DNA damage response (DD...

    Maria Rita Fabbrizi, Barbara Meyer, Sandeep Misri, Suyash Raj… in Cell Death & Disease (2018)

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  3. No Access

    Chapter

    Cytosolic Phospholipase A2 and Autotaxin Inhibitors as Potential Radiosensitizers

    Several classes of lipid mediators are initially derived through the action of phospholipase A2 (PLA2) enzymes on phospholipids that release fatty acids and lysophospholipids. Both fatty acids and lysophospholipi...

    Dinesh Thotala, Andrei Laszlo, Dennis E. Hallahan in Phospholipases in Health and Disease (2014)