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  1. Article

    Open Access

    Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein

    Preventing the protein-protein interaction of the cellular chromatin binding protein Lens Epithelium-Derived Growth Factor (LEDGF) and human immunodeficiency virus (HIV) integrase is an important possible stra...

    Leyuan Bao, Clare Hannon, Abimael Cruz-Mignoni, Denis Ptchelkine… in Scientific Reports (2017)

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  2. Article

    Open Access

    Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging

    Archaeal viruses have evolved to infect hosts often thriving in extreme conditions such as high temperatures. However, there is a paucity of information on archaeal virion structures, genome packaging, and det...

    Denis Ptchelkine, Ashley Gillum, Tomohiro Mochizuki… in Nature Communications (2017)

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  3. No Access

    Article

    5-Formylcytosine does not change the global structure of DNA

    X-ray crystallography and NMR analysis demonstrate that, contrary to previous observations, fC does not significantly alter DNA structure, thus suggesting an alternative basis for recognition of fC-DNA by epigeno...

    Jack S Hardwick, Denis Ptchelkine… in Nature Structural & Molecular Biology (2017)