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  1. Article

    Open Access

    Haemophagocytic lymphohistiocytosis caused by GATA2 deficiency: a report on three patients

    Haemophagocytic lymphohistiocytosis (HLH) is a syndrome that occurs in patients with severe systemic hyperinflammation. GATA binding protein 2 (GATA2) is a transcription factor and key component in haematopoiesis...

    Lin Wu, **gshi Wang, Deli Song, Yahong You, Zhao Wang in BMC Infectious Diseases (2024)

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  2. No Access

    Article

    Progesterone induces glioblastoma cell apoptosis by coactivating extrinsic and intrinsic apoptotic pathways

    Glioblastoma is a common and lethal primary brain tumor with a mean survival time less than 2 years. Progesterone, a natural steroid hormone, is a small molecule with distinct effects on glioblastoma cells. Hi...

    Yasi Zhou, **ao **ao, Chuyin Peng, Deli Song, Fan Ouyang… in Molecular & Cellular Toxicology (2024)

  3. No Access

    Article

    STT3A-mediated viral N-glycosylation underlies the tumor selectivity of oncolytic virus M1

    Oncolytic viruses are emerging as promising anticancer agents. Although the essential biological function of N-glycosylation on viruses are widely accepted, roles of N-glycan and glycan-processing enzyme in on...

    Deli Song, Xudong Jia, Yuanzhu Gao, Tong **ao, Jia Dan, Runling Shen, **g Cai… in Oncogene (2023)

  4. Article

    Open Access

    Directed natural evolution generates a next-generation oncolytic virus with a high potency and safety profile

    Oncolytic viruses (OVs) represent a type of encouraging multi-mechanistic drug for the treatment of cancer. However, attenuation of virulence, which is generally required for the development of OVs based on pa...

    Li Guo, Cheng Hu, Yang Liu, **aoyu Chen, Deli Song, Runling Shen… in Nature Communications (2023)

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  5. Article

    Open Access

    Identification of the receptor of oncolytic virus M1 as a therapeutic predictor for multiple solid tumors

    Over the last decade, oncolytic virus (OV) therapy has shown its promising potential in tumor treatment. The fact that not every patient can benefit from it highlights the importance for defining biomarkers th...

    Deli Song, Xudong Jia, **ncheng Liu, Linyi Hu… in Signal Transduction and Targeted Therapy (2022)

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  6. No Access

    Article

    Necroptotic virotherapy of oncolytic alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC

    Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype among breast tumors and remains a challenge even for the most current therapeutic regimes. Here, we demonstrate that oncolytic alph...

    Jiayu Zhang, Ying Liu, **gyi Tan, Yanming Zhang, Chun-Wa Wong, Ziqing Lin… in Oncogene (2021)