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Chapter
Obesity-Mediated Alterations in Immune Function, Host Defense, and Lung Disease
Obesity is one of the foremost chronic conditions affecting humans globally and is associated with myriad diseases affecting most organs, including the lungs. One of the underlying mechanisms is its effect on ...
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Article
Complications associated with incorrect use of nasal CPAP
Nasal continuous positive airway pressure (nCPAP) is a safe, effective, non-invasive respiratory modality to deliver positive end expiratory pressure in neonates. Many studies have established its associated i...
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Article
Open AccessBurden and unmet need for specialist care in poorly controlled and severe childhood asthma in a Danish nationwide cohort
Asthma is a common disease in childhood and adolescence with lifelong consequences particularly among those at risk of severe disease, poor control and/or frequent exacerbations. Specialist care is recommended...
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Article
Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma
Obesity-related asthma is associated with a high disease burden and a poor response to existent asthma therapies, suggesting that it is a distinct asthma phenotype. The proposed mechanisms that contribute to o...
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Article
Open AccessAfrican-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans
Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry.
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Article
Defining pediatric asthma: phenotypes to endotypes and beyond
Asthma is the most common chronic pediatric lung disease that has traditionally been defined as a syndrome of airway inflammation characterized by clinical symptoms of cough and wheeze. Highlighting the comple...
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Chapter
Severe Asthma in Childhood: Special Considerations
Severe asthma in children is often notable for frequent exacerbations that drive fear and life disruption for child and family, and may contribute to poor airways growth. This chapter distinguishes severe asth...
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Article
Weaning of nasal CPAP in preterm infants: who, when and how? a systematic review of the literature
There is increased use of early nasal continuous positive airway pressure (NCPAP) to manage respiratory distress in preterm infants but optimal methods and factors associated with successful wean are not well ...
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Article
Open AccessDifferential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma
While DNA methylation plays a role in T-helper (Th) cell maturation, its potential dysregulation in the non-atopic Th1-polarized systemic inflammation observed in obesity-associated asthma is unknown. We studi...
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Article
Pseudohypoparathyroidism-albright hereditary osteodystrophy
A 13 year old girl with short stature, and retarded mental growth with coarse facies and deranged thyroid function test was initially suspected as a case of hypothyroidism and was started on thyroxine. Lack of...
