-
Article
Open AccessAnalytical Characterization for Similarity Assessment Between an Aflibercept Biosimilar SB15 and Reference Product (Eylea®)
SB15 is a proposed biosimilar product of reference aflibercept (Eylea®), an approved biological drug product for retinal diseases including neovascular age-related macular degeneration (nAMD). This study aimed to...
-
Article
Open AccessImproving home-like environments in long-term care units: an exploratory mixed-method study
Although the number of older adults requiring care is rapidly increasing, nursing homes have long faced issues such as the absence of a home-like environment. This exploratory mixed-method study investigated h...
-
Article
Open AccessLong-term cardiovascular outcome in women with preeclampsia in Korea: a large population-based cohort study and meta-analysis
Recent studies reported the long-term cardiovascular risk of preeclampsia. However, only a few studies have investigated the association between preeclampsia and long-term cardiovascular disease in Asian popul...
-
Article
Open AccessCompletely annealing-free flexible Perovskite quantum dot solar cells employing UV-sintered Ga-doped SnO2 electron transport layers
The electron transport layer (ETL) is a critical component in perovskite quantum dot (PQD) solar cells, significantly impacting their photovoltaic performance and stability. Low-temperature ETL deposition meth...
-
Article
Open AccessRejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
Age-dependent accumulation of amyloid plaques in patients with sporadic Alzheimer’s disease (AD) is associated with reduced amyloid clearance. Older microglia have a reduced ability to phagocytose amyloid, so ...
-
Article
A Multi-layered Illustration of Exemplary Business Ethics Practices with Voices of the Engineers in the Health Products Industry
Promoting ethical practice within an organization has been a continuous challenge in the business ethics community. To enrich organizational practices for promoting business ethics across an organization, this...
-
Article
Stealing Time on the Company’s Dime: Examining the Indirect Effect of Laissez-Faire Leadership on Employee Time Theft
Employee time theft is a costly and prevalent unethical work behavior. Yet, this construct has received less attention compared to other unethical behaviors, and as such, the literature has only a rudimentary ...
-
Article
Flexible TDMA System for the Efficient Microwave Power Transmission to Multiple Power Receiver
Basically, wireless microwave power transfer system has very low power delivery efficiency and this efficiency gets extremely lower as the longer range and higher center frequency. Also, there is no room for t...
-
Article
Open AccessA pilot study of nailfold capillaroscopy in hereditary transthyretin amyloidosis
Nailfold capillaroscopy (NFC) is a safe and non-invasive imaging tool for evaluating microvascular abnormalities. This retrospective cross-sectional study aimed to analyze the NFC outcomes and clinical charact...
-
Article
Open AccessAssessing the impact of novelty and conformity on hesitancy towards COVID-19 vaccines using mRNA technology
Public hesitancy towards Covid-19 vaccines remains a major hurdle for mass vaccination programs today. While mRNA vaccines are more efficacious than conventional vaccines, it is unknown how much the novelty of...
-
Article
Senior Engineering Students’ Reflection on Their Learning of Ethics and Morality: A Qualitative Investigation of Influences and Lessons Learned
Informed by ABET accreditation criteria and broader societal needs, ethics has been emphasized as important for engineering professionals. Engineering students are thus exposed to professional ethics and relat...
-
Article
The Nasal Vestibular Body and Its Role in Nasal Obstruction
The nasal vestibular body (NVB) is a recently reported, dynamic swell body present in the anterior nasal airway that may contribute to symptomatic nasal airway obstruction. This review aims to summarize what i...
-
Chapter
Nasal Septum Perforation and Inferior Turbinate Avulsion/Unilateral Empty Nose Syndrome Resulting from Management of Recurrent Epistaxis
The patient is a 68-year-old male who reported a history of excellent health until 10 years ago, when he developed a cardiac/thromboembolic condition that required use of aspirin and clopidogrel for anticoagul...
-
Chapter
New Product Development: Trade-offs, Metrics, and Successes
This chapter reviews Morris Cohen’s scholarly contributions to new product development (NPD) and the other areas at the interface of marketing and production. Specifically, we examine how Morris and his co-aut...
-
Article
Open AccessSteady-state kinetic analysis of mitochondrial respiratory enzymes from bovine heart mitochondria
Mitochondria is a decisive organelle of cells that produces adenosine triphosphate (ATP) by the process of oxidative phosphorylation of the Krebs cycle and the electron transport chain. The electron transport ...
-
Article
Open AccessACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs
The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the pathogenesis of SARS-CoV-2. We i...
-
Article
Open AccessStratified layer analysis reveals intrinsic leptin stimulates cryptal mesenchymal cells for controlling mucosal inflammation
Mesenchymal cells in the crypt play indispensable roles in the maintenance of intestinal epithelial homeostasis through their contribution to the preservation of stem cells. However, the acquisition properties...
-
Article
Application of deep learning to the diagnosis of cervical lymph node metastasis from thyroid cancer with CT: external validation and clinical utility for resident training
This study aimed to validate a deep learning model’s diagnostic performance in using computed tomography (CT) to diagnose cervical lymph node metastasis (LNM) from thyroid cancer in a large clinical cohort and...
-
Article
Engineered Co-culture Strategies Using Stem Cells for Facilitated Chondrogenic Differentiation and Cartilage Repair
Osteoarthritis (OA) is a chronic disease in elders and athletes due to limited regenerative capacities of cartilage tissues and subsequently insufficient recovery of damaged sites. Recent clinical treatments f...
-
Article
Design and synthesis of 2,3-dihydro- and 5-chloro-2,3-dihydro-naphtho-[1,2-b]furan-2-carboxylic acid N-(substitutedphenyl)amide analogs and their biological activities as inhibitors of NF-κB activity and anticancer agents
A series of 2,3-dihydro- and 5-chloro-2,3-dihydro-naphtho-[1,2-b]furan-2-carboxylic acid N-(substitutedphenyl)amide analogs (1a–k and 2a–i) were designed and synthesized for develo** novel naphthofuran scaffold...
