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Open AccessFree sugar intake from snacks and beverages in Canadian preschool- and toddler-aged children: a cross-sectional study
Excess consumption of free sugar (FS) increases the risk of dental caries and unhealthy weight gain. However, the contribution of snacks and beverages to young children’s FS intake is not well understood. The ...
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The Effect of Dietary n-3 Polyunsaturated Fatty Acids on Non-obese and Obesity-Associated Breast Cancer
Globally, breast cancer is the most diagnosed type of cancer in females, wherein almost half of all breast cancer will develop some form of metastatic disease. Lifestyle factors including diet and physical act...
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Article
Open AccessThe effect of omega-3 fatty acids on a biomarker of head trauma in NCAA football athletes: a multi-site, non-randomized study
American-style football (ASF) athletes are at risk for cardiovascular disease (CVD) and exhibit elevated levels of serum neurofilament light (Nf-L), a biomarker of axonal injury that is associated with repetit...
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Open AccessAssociation between diet quality and food waste in Canadian families: a cross-sectional study
Higher diet quality has been associated with greater amounts of food waste among adults in the United States. This study aims to build on previous work by examining the association between diet quality and foo...
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Open AccessA randomized home-based childhood obesity prevention pilot intervention has favourable effects on parental body composition: preliminary evidence from the Guelph Family Health Study
Home-based lifestyle behaviour interventions show promise for treating and preventing childhood obesity. According to family theories, engaging the entire family unit, including parents, to change their family...
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Open AccessMothers’ and fathers’ media parenting practices associated with young children’s screen-time: a cross-sectional study
A major contributor to the growing obesity crisis is screen based sedentary behaviour among young children. Media parenting practices may be an important determinant of children’s screen time, however publishe...
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Guelph Family Health Study: pilot study of a home-based obesity prevention intervention
To examine the feasibility and preliminary impact of a home-based obesity prevention intervention among Canadian families.
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Open AccessA review of the effect of omega-3 polyunsaturated fatty acids on blood triacylglycerol levels in normolipidemic and borderline hyperlipidemic individuals
Circulating levels of triacylglycerol (TG) is a recognized risk factor for develo** cardiovascular disease, a leading cause of death worldwide. The Institute of Medicine and the American Heart Association bo...
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Open AccessThe iFat1 transgene permits conditional endogenous n-3 PUFA enrichment both in vitro and in vivo
Fat-1 transgenic mice, which endogenously convert n-6 PUFA to n-3 PUFA, are a useful tool in health research; however with this model timing of n-3 PUFA enrichment cannot be directly controlled. To add such ca...
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Plasma Levels of 14:0, 16:0, 16:1n-7, and 20:3n-6 are Positively Associated, but 18:0 and 18:2n-6 are Inversely Associated with Markers of Inflammation in Young Healthy Adults
Inflammation is a recognized risk factor for the development of chronic diseases, such as type 2 diabetes and atherosclerosis. Evidence suggests that individual fatty acids (FA) may have distinct influences o...
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Carcinogenesis alters fatty acid profile in breast tissue
Cancerogenesis is associated with cell membrane changes. The aim of this study was to investigate whether breast tissues with different degrees of cancer involvement have different fatty acid profiles. Fourtee...
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The Fat-1 Mouse has Brain Docosahexaenoic Acid Levels Achievable Through Fish Oil Feeding
Fat-1 transgenic mice endogenously convert n-6 to n-3 polyunsaturated fatty acids (PUFA). The aims of this study were to test whether a) fish oil feeding can attain similar brain n-3 PUFA levels as the fat-1 m...
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‘Designer oils’ low in n-6:n-3 fatty acid ratio beneficially modifies cardiovascular risks in mice
Cardiovascular benefits of dietary n-3 fatty acids have been shown. However, benefits of n-3 fatty acids as part of a high fat, low n-6:n-3 fatty acid ratio diet has not been fully characterized. Aim of this s...
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A Novel Role for Nutrition in the Alteration of Functional Microdomains on the Cell Surface
Membrane rafts are ordered microdomains of the plasma membrane consisting of cholesterol, sphingolipids, and saturated fatty acids which appear to regulate many cellular signaling pathways. One such type of me...
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n-3 polyunsaturated fatty acids endogenously synthesized in fat-1 mice are enriched in the mammary gland
In this study, we determined the phospholipid FA composition in the mammary gland of the transgenic Fat-1 mouse. This is the first animal model developed that can endogenously synthesize n−3 PUFA. The synthesi...
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Countercurrent approach to the enrichment of Δ9c,11t-and Δ10t,12c-18:2 isomers by urea complexation
CLA refers to a group of geometrical and positional isomers of linoleic acid. CLA has been shown to have potentially beneficial effects on cancer, atherosclerosis, and body metabolism in animals. Mixtures cont...
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Preparation of conjugated linoleic acid from safflower oil
Synthetically prepared mixtures of conjugated linoleic acid (CLA) are widely used in animal and cell culture studies to investigate the potential effects of the Δ9c, 11t-18:2 isomer found in food products from ru...
