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Open AccessTick hemocytes have a pleiotropic role in microbial infection and arthropod fitness
Uncovering the complexity of systems in non-model organisms is critical for understanding arthropod immunology. Prior efforts have mostly focused on Dipteran insects, which only account for a subset of existin...
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Open AccessGene expression analyses reveal differences in children’s response to malaria according to their age
In Bandiagara, Mali, children experience on average two clinical malaria episodes per year. However, even in the same transmission area, the number of uncomplicated symptomatic infections, and their parasitemi...
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Open AccessSTRIDE: a command-line HMM-based identifier and sub-classifier of Plasmodium falciparum RIFIN and STEVOR variant surface antigen families
RIFINs and STEVORs are variant surface antigens expressed by P. falciparum that play roles in severe malaria pathogenesis and immune evasion. These two highly diverse multigene families feature multiple paralogs,...
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Open AccessRelative contributions of various endogenous and exogenous factors to the mosquito microbiota
The commensal microbiota of mosquitoes impacts their development, immunity, and competency, and could provide a target for alternative entomological control approaches. However, despite the importance of the m...
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Open AccessOptimization of parasite DNA enrichment approaches to generate whole genome sequencing data for Plasmodium falciparum from low parasitaemia samples
Owing to the large amount of host DNA in clinical samples, generation of high-quality Plasmodium falciparum whole genome sequencing (WGS) data requires enrichment for parasite DNA. Enrichment is often achieved by...
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Open AccessPlasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross
Mainstay treatment for Plasmodium vivax malaria has long relied on chloroquine (CQ) against blood-stage parasites plus primaquine against dormant liver-stage forms (hypnozoites), however drug resistance confronts...
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Open AccessPlasmodium vivax transcriptomes reveal stage-specific chloroquine response and differential regulation of male and female gametocytes
Studies of Plasmodium vivax gene expression are complicated by the lack of in vitro culture system and the difficulties associated with studying clinical infections that often contain multiple clones and a mixtur...
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Article
Open AccessA high-throughput sequencing assay to comprehensively detect and characterize unicellular eukaryotes and helminths from biological and environmental samples
Several of the most devastating human diseases are caused by eukaryotic parasites transmitted by arthropod vectors or through food and water contamination. These pathogens only represent a fraction of all unic...
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Article
Open AccessFactors sha** the gut bacterial community assembly in two main Colombian malaria vectors
The understanding of the roles of gut bacteria in the fitness and vectorial capacity of mosquitoes that transmit malaria, is improving; however, the factors sha** the composition and structure of such bacter...
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Open AccessCharacterization of P. vivax blood stage transcriptomes from field isolates reveals similarities among infections and complex gene isoforms
Our understanding of the structure and regulation of Plasmodium vivax genes is limited by our inability to grow the parasites in long-term in vitro cultures. Most P. vivax studies must therefore rely on patient s...
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Open AccessGenomic analyses of complex P. vivax infections
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Open AccessMitochondrial genome sequences reveal deep divergences among Anopheles punctulatus sibling species in Papua New Guinea
Members of the Anopheles punctulatus group (AP group) are the primary vectors of human malaria in Papua New Guinea. The AP group includes 13 sibling species, most of them morphologically indistinguishable. Unders...
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Erratum: Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
Nat. Genet. 41, 1110–1115; published online 6 September; corrected online 13 September 2009 In the version of this article initially published online, there were errors in the e-mail addresses of two of the co...
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Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
Rob Sladek and colleagues identify a common variant near the insulin receptor substrate 1 gene (IRS1) associated with type 2 diabetes, insulin resistance, hyperinsulinemia and impaired insulin signaling. This is ...
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A genome-wide approach to identifying novel-imprinted genes
Genomic imprinting is an epigenetic process in which the copy of a gene inherited from one parent (maternal or paternal) is consistently silenced or expressed at a significantly lower level than the copy from ...
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Neanderthals in central Asia and Siberia
The classic frame of the Neanderthals — stocky, long-headed, with distinctive features of the skull — began to emerge around 400,000 years ago, and disappeared from hominins around 30,000 years ago. However, d...
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A genome-wide association study identifies novel risk loci for type 2 diabetes
Type 2 diabetes mellitus results from the interaction of environmental factors with a combination of genetic variants, most of which were hitherto unknown. A systematic search for these variants was recently m...
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No Evidence of Neandertal mtDNA Contribution to Early Modern Humans
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Ancient DNA
DNA-sequence information can, in principle, be retrieved from archaeological and palaeontological remains that are less than ∼100,000 years old.
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