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Article
Open AccessConserved epigenetic hallmarks of T cell aging during immunity and malignancy
Chronological aging correlates with epigenetic modifications at specific loci, calibrated to species lifespan. Such ‘epigenetic clocks’ appear conserved among mammals, but whether they are cell autonomous and ...
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Article
Open AccessTissue-resident B cells orchestrate macrophage polarisation and function
B cells play a central role in humoral immunity but also have antibody-independent functions. Studies to date have focused on B cells in blood and secondary lymphoid organs but whether B cells reside in non-ly...
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Article
CD4+ T cell memory
Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–peptide complexes to control phagosomal infections, help B cells, regulate tissue homeostasis and repair or perform immu...
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Article
Open AccessFGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells
Although tissue-resident memory T (TRM) cells specific for previously encountered pathogens have been characterized, the induction and recruitment of brain TRM cells following immune therapy has not been observed...
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Article
Functional T cells are capable of supernumerary cell division and longevity
Differentiated somatic mammalian cells putatively exhibit species-specific division limits that impede cancer but may constrain lifespans1–3. To provide immunity, transiently stimulated CD8+ T cells undergo unusu...
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Article
Correction to: Functional virus‑specific memory T cells survey glioblastoma
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Functional virus-specific memory T cells survey glioblastoma
Glioblastoma multiforme (GBM) is among the most aggressive, treatment-resistant cancers, and despite standard of care surgery, radiation and chemotherapy, is invariably fatal. GBM is marked by local and system...
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Article
The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against pathogens and malignancies, and the molecular processes that lead to TRM cell formation are therefore of substantial biomed...
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Article
Expansible residence decentralizes immune homeostasis
In metazoans, specific tasks are relegated to dedicated organs that are established early in development, occupy discrete locations and typically remain fixed in size. The adult immune system arises from a cen...
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Article
Open AccessT cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers
Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques wit...
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Developmental plasticity allows outside-in immune responses by resident memory T cells
Central memory T (TCM) cells patrol lymph nodes and perform conventional memory responses on restimulation: proliferation, migration and differentiation into diverse T cell subsets while also self-renewing. Resid...
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Open AccessVirus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
The immunosuppressive tumor microenvironment limits the success of current immunotherapies. The host retains memory T cells specific for previous infections throughout the entire body that are capable of execu...
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Article
The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells
Extracellular ATP (eATP) is an ancient ‘danger signal’ used by eukaryotes to detect cellular damage1. In mice and humans, the release of eATP during inflammation or injury stimulates both innate immune activation...
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Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory
CD8+ T cell immunosurveillance dynamics influence the outcome of intracellular infections and cancer. Here we used two-photon intravital microscopy to visualize the responses of CD8+ resident memory T cells (TRM ...
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Article
Open AccessStable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning
Human microbiota-associated (HMA) animal models relying on germ-free recipient mice are being used to study the relationship between intestinal microbiota and human disease. However, transfer of microbiota int...
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Article
Tissue-resident memory T cells live off the fat of the land
The consumption of exogenous free fatty acids by tissue-resident memory T (Trm) cells is critical for their long-term survival and antiviral function, and appears to be a conserved feature of Trm cells in both mo...
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Article
Resident memory T cells are a Notch above the rest
Notch signaling promotes the maintenance of lung-resident CD8+ memory T cells that are transcriptionally poised for rapid effector responses but have heightened expression of inhibitory receptors, suggestive of t...
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Article
Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β
The cytokine TGF-β maintains the residency of cells of the immune system in barrier tissues. Kaplan and colleagues demonstrate that specific integrins expressed by epithelial cells activate latent TGF-β and th...
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Article
Normalizing the environment recapitulates adult human immune traits in laboratory mice
The immune system of laboratory mice raised in an ultra-hygienic environment resembles that ofnewborn humans, but can be induced to resemble the immune system of adult humans or 'dirty' mice by co-housing with...
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Article
Open AccessNK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade
Melanoma is one of the few types of cancer with an increasing annual incidence. While a number of immunotherapies for melanoma have been associated with significant clinical benefit, including high-dose IL-2 a...
