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Drug Discovery from Natural Sources
A discussion of the role of natural products as drugs and/or following partial or complete chemical synthesis, have been approved human use drugs in at least one country, or alternatively is/are the source of ...
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Book
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Chapter
The Status of Plant and Plant–Microbe Interactions Related to Medicinal Agents
For millennia, medicinal plants have been the source of medicines initially for everyone, but since approximately the middle of the twentieth century, in the West, their use has been decreasing significantly a...
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Chapter
Bioactive Compounds from Extremophilic Marine Fungi
The marine world is the largest underexplored ecosystem for bioactive compounds due to its inaccessibility beyond the intertidal, hindering the isolation of new chemical entities. There is reason to explore ma...
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Chapter
Natural Products as Sources of Anticancer Agents: Current Approaches and Perspectives
Natural products from marine invertebrates and microbes from terrestrial (and marine) sources together with higher plants have been an important source of many clinically useful anticancer agents. Over 60% of ...
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Book
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Book
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Book
Bioactive Compounds from Extremophiles
Genomic Studies, Biosynthetic Gene Clusters, and New Dereplication Methods
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Chapter
Bioactive Compounds from Marine Extremophiles
With the development of the self-contained underwater breathing apparatus (SCUBA) and other recently developed marine collecting techniques, numerous bioactive secondary metabolites have been isolated and char...
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Chapter
Bioactive Compounds from Extremophiles
Microorganisms continue to serve as valuable sources of natural product therapeutics for the treatment of disease, evidenced by roughly 50 % of approved small molecule antitumor drugs being either directly fro...
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Chapter
Bioactive Compounds from Terrestrial Extremophiles
Since the 1960s, bioactive secondary metabolites have been isolated and structurally characterized from eubacteria, archaea, and fungi, microorganisms that have adopted strategies to grow in extreme terrestria...
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Article
Natural products as leads to antitumor drugs
The discussion in this short review emphasizes that the main and future source of novel natural products as leads to antitumor agents is probably in the areas of biology that cannot be seen, i.e. the microbial...
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Article
Microbial natural products: molecular blueprints for antitumor drugs
Microbes from two of the three domains of life, the Prokarya, and Eukarya, continue to serve as rich sources of structurally complex chemical scaffolds that have proven to be essential for the development of a...
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Chapter
The National Cancer Institute and Natural Product-Based Drug Discovery in Africa
In the experience of the US National Cancer Institute, African biodiversity has been the source of several promising anticancer drugs. Analogues of the combretastatins are in advanced clinical trials, while co...
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Reference Work Entry In depth
Legal and Ethical Issues Involving Marine Biodiscovery and Development
The discovery and development of novel, biologically active agents from natural sources, whether they be drugs, agrochemicals, or other bioactive entities, involve a high level of interdisciplinary as well as ...
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Reference Work Entry In depth
Meeting the Supply Needs of Marine Natural Products
Perhaps the major perception both in the general medical and scientific communities, and also to some extent in the natural products community, is that marine natural products are of interest but not directly ...
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Article
Characterization of Silvestrol Pharmacokinetics in Mice Using Liquid Chromatography–Tandem Mass Spectrometry
A sensitive and specific liquid chromatography–tandem mass spectrometry method was developed and validated for the quantification of the plant natural product silvestrol in mice, using ansamitocin P-3 as the i...
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Chapter
Mother Nature’s gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery
This chapter is designed to demonstrate that compounds derived from nature are still in the forefront of drug discovery in diseases such as microbial and parasitic infections, carcinomas of many types and cont...
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Article
New drugs from marine microbes: the tide is turning
This is a mini-review demonstrating that investigation of the genomics of marine microbes from all three domains has the potential to revolutionize the search for secondary metabolites originally thought to be...
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Chapter
The Camptothecin Experience: From Chinese Medicinal Plants to Potent Anti-Cancer Drugs
Camptothecin is a potent natural product based anticancer agent isolated from an organic extract of the bark of a Chinese tree, Camptotheca acuminata, Decaisne (Nyssaceae). The chemical identification of camptoth...
