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Article
Open AccessExploring the use of Rasch modelling in “common content” items for multi-site and multi-year assessment
Rasch modelling is a powerful tool for evaluating item performance, measuring drift in difficulty over time, and comparing students who sat assessments at different times or at different sites. Here, we use da...
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Article
Open AccessVignettes: an innovative qualitative data collection tool in Medical Education research
This article describes how to make use of exemplar vignettes in qualitative medial education research. Vignettes are particularly useful in prompting discussion with participants, when using real-life case exa...
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Article
Open AccessMucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques
A limitation of current SARS-CoV-2 vaccines is that they provide minimal protection against infection with current Omicron subvariants1,2, although they still provide protection against severe disease. Enhanced m...
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Article
Open AccessBooster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques
Omicron spike (S) encoding vaccines as boosters, are a potential strategy to improve COVID-19 vaccine efficacy against Omicron. Here, macaques (mostly females) previously immunized with Ad26.COV2.S, are booste...
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Article
Open AccessImmunogenicity and protective efficacy of GBP510/AS03 vaccine against SARS-CoV-2 delta challenge in rhesus macaques
Despite the availability of several effective SARS-CoV-2 vaccines, additional vaccines will be required for optimal global vaccination. In this study, we investigate the immunogenicity and protective efficacy ...
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Article
Open AccessTarget receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells
Cellular therapies offer a promising therapeutic strategy for the highly malignant brain tumor, glioblastoma (GBM). However, their clinical translation is limited by the lack of effective target identification...
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Article
Open AccessOptimization of non-coding regions for a non-modified mRNA COVID-19 vaccine
The CVnCoV (CureVac) mRNA vaccine for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was recently evaluated in a phase 2b/3 efficacy trial in humans1. CV2CoV is a second-generation mRNA vaccine cont...
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Article
Open AccessVariation in performance on common content items at UK medical schools
Due to differing assessment systems across UK medical schools, making meaningful cross-school comparisons on undergraduate students’ performance in knowledge tests is difficult. Ahead of the introduction of a ...
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Article
Open AccessEffect of remote online exam delivery on student experience and performance in applied knowledge tests
The use of remote online delivery of summative assessments has been underexplored in medical education. Due to the COVID-19 pandemic, all end of year applied knowledge multiple choice question (MCQ) tests at o...
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Article
Open AccessUsing differential item functioning to evaluate potential bias in a high stakes postgraduate knowledge based assessment
Fairness is a critical component of defensible assessment. Candidates should perform according to ability without influence from background characteristics such as ethnicity or sex. However, performance differ...
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Chapter and Conference Paper
MaxMax: A Graph-Based Soft Clustering Algorithm Applied to Word Sense Induction
This paper introduces a linear time graph-based soft clustering algorithm. The algorithm applies a simple idea: given a graph, vertex pairs are assigned to the same cluster if either vertex has maximal affinit...
