4 Result(s)
within
David Furman
Molecular Medicine
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Article
Association of biological aging with frailty and post-transplant outcomes among adults with cirrhosis
Frailty is classically associated with advanced age but is also an important predictor of clinical outcomes in comparatively young adults with cirrhosis. We examined the association of biological aging with fr...
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Article
Chronic inflammation in the etiology of disease across the life span
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote...
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Article
A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring
Immune responses generally decline with age. However, the dynamics of this process at the individual level have not been characterized, hindering quantification of an individual’s immune age. Here, we use mult...
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Article
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
Differential expression of inflammasome gene modules and inflammasome-activating metabolites correlates with interleukin-1β expression, hypertension, arterial stiffness and longevity in older individuals.
