28 Result(s)
within
David Bell
Public Health
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Article
Open AccessEvaluation of a haemozoin-based rapid diagnostic test for diagnosis of imported malaria during the phase of prevention of reestablishment in Sri Lanka
Sri Lanka, an island nation, has eliminated endemic malaria transmission. Maintaining elimination in the continued presence of vectors requires vigilance in screening people travelling from high malaria-risk a...
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Open AccessPerformance of a fully‐automated system on a WHO malaria microscopy evaluation slide set
Manual microscopy remains a widely-used tool for malaria diagnosis and clinical studies, but it has inconsistent quality in the field due to variability in training and field practices. Automated diagnostic sy...
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Open AccessTowards harmonization of microscopy methods for malaria clinical research studies
Microscopy performed on stained films of peripheral blood for detection, identification and quantification of malaria parasites is an essential reference standard for clinical trials of drugs, vaccines and dia...
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Article
Development and Initial Evaluation of a Multifaceted Intervention to Improve Mental Health and Quality of Life Among Prostate Cancer Survivors
Mental health issues affect a third of prostate cancer (PCa) survivors. Here, we describe the development and preliminary evaluation of a unique multifaceted intervention, the Prostate Cancer–Patient Empowerme...
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Open AccessKeep the quality high: the benefits of lot testing for the quality control of malaria rapid diagnostic tests
The production and use of malaria rapid diagnostic tests (RDTs) has risen dramatically over the past 20 years. In view of weak or non-existing in vitro diagnostics (IVD) regulations and post-marketing surveill...
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Open AccessA review of the WHO malaria rapid diagnostic test product testing programme (2008–2018): performance, procurement and policy
Malaria rapid diagnostic tests (RDTs) emerged in the early 1990s into largely unregulated markets, and uncertain field performance was a major concern for the acceptance of tests for malaria case management. T...
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Open AccessAutomated microscopy for routine malaria diagnosis: a field comparison on Giemsa-stained blood films in Peru
Microscopic examination of Giemsa-stained blood films remains a major form of diagnosis in malaria case management, and is a reference standard for research. However, as with other visualization-based diagnose...
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Open AccessQuantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group
The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Viv...
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Open AccessDetection of Plasmodium knowlesi, Plasmodium falciparum and Plasmodium vivax using loop-mediated isothermal amplification (LAMP) in a co-endemic area in Malaysia
Plasmodium knowlesi is the most common cause of malaria in Malaysia. However, microscopic diagnosis is inaccurate and rapid diagnostic tests (RDTs) are insufficiently sensitive. PCR is...
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Open AccessDevelopment of new malaria diagnostics: matching performance and need
Despite advances in diagnostic technology, significant gaps remain in access to malaria diagnosis. Accurate diagnosis and misdiagnosis leads to unnecessary waste of resources, poor disease management, and cont...
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Open AccessThe design and evaluation of a shaped filter collection device to sample and store defined volume dried blood spots from finger pricks
Dried blood spots are a common medium for collecting patient blood prior to testing for malaria by molecular methods. A new shaped filter device for the quick and simple collection of a designated volume of pa...
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Open AccessLoop-mediated isothermal amplification (LAMP) for point-of-care detection of asymptomatic low-density malaria parasite carriers in Zanzibar
Asymptomatic, low parasite density malaria infections are difficult to detect with currently available point-of-care diagnostics. This study piloted a loop-mediated isothermal amplification (LAMP) kit for fiel...
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Open AccessCirculating antibodies against Plasmodium falciparum histidine-rich proteins 2 interfere with antigen detection by rapid diagnostic tests
Rapid diagnostic tests (RDTs) for detection of Plasmodium falciparum infection that target P. falciparum histidine-rich protein 2 (PfHRP2), a protein that circulates in the blood of patients infected with this sp...
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Open AccessCharacterization of specimens for quality control of malaria rapid diagnostic tests: what is the best indicator for performance?
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Open AccessPlasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting
Malaria rapid diagnostic tests (RDTs) play a critical role in malaria case management, surveillance and case investigations. Test performance is largely determined by design and quality characteristics, such a...
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Open AccessMalaria rapid diagnostic test transport and storage conditions in Burkina Faso, Senegal, Ethiopia and the Philippines
As more point of care diagnostics become available, the need to transport and store perishable medical commodities to remote locations increases. As with other diagnostics, malaria rapid diagnostic tests (RDTs...
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Open AccessDevelo** standards for malaria microscopy: external competency assessment for malaria microscopists in the Asia-Pacific
Malaria diagnosis has received renewed interest in recent years, associated with the increasing accessibility of accurate diagnosis through the introduction of rapid diagnostic tests and new World Health Organ...
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Open AccessMolecular diagnosis for screening and elimination of malaria: performance of the first commercially-available malaria LAMP test
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Open AccessFinding parasites and finding challenges: improved diagnostic access and trends in reported malaria and anti-malarial drug use in Livingstone district, Zambia
Understanding the impact of malaria rapid diagnostic test (RDT) use on management of acute febrile disease at a community level, and on the consumption of anti-malarial medicines, is critical to the planning a...
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Open AccessA survey of engagement and competence levels in interventions and activities in a community mental health workforce in England
National Health Service (NHS) mental health workforce configuration is at the heart of successful delivery, and providers are advised to produce professional development strategies. Recent policy changes in En...
