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Article
Open AccessEfficient synthesis of limonene production in Yarrowia lipolytica by combinatorial engineering strategies
Limonene has a variety of applications in the foods, cosmetics, pharmaceuticals, biomaterials, and biofuels industries. In order to meet the growing demand for sustainable production of limonene at industry sc...
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Article
Open AccessPatient-reported outcomes and healthcare resource utilization in systemic lupus erythematosus: impact of disease activity
Limited real-world data exists on clinical outcomes in systemic lupus erythematosus (SLE) patients by SLE Disease Activity Index 2000 (SLEDAI-2 K), hereafter, SLEDAI. We aimed to examine the association betwee...
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Article
Open AccessBlazing the trail for innovative tuberculosis diagnostics
The COVID-19 pandemic brought diagnostics into the spotlight in an unprecedented way not only for case management but also for population health, surveillance, and monitoring. The industry saw notable levels o...
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Article
Open AccessVariants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation
WDR44 prevents ciliogenesis initiation by regulating RAB11-dependent vesicle trafficking. Here, we describe male patients with missense and nonsense variants within the WD40 repeats (WDR) of WDR44, an X-linked...
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Article
Open AccessPerformance evaluation of the AiDx multi-diagnostic automated microscope for the detection of schistosomiasis in Abuja, Nigeria
In this research, we report on the performance of automated optical digital detection and quantification of Schistosoma haematobium provided by AiDx NTDx multi-diagnostic Assist microscope. Our study was communit...
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Article
Open AccessEvaluation of a point-of-care haemozoin assay (Gazelle device) for rapid detection of Plasmodium knowlesi malaria
Plasmodium knowlesi is the major cause of zoonotic malaria in Southeast Asia. Rapid and accurate diagnosis enables effective clinical management. A novel malaria diagnostic tool, Gazelle (Hemex Health, USA) detec...
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Preparation of Simulation Chambers for Experiments
When setting up a simulation chamber experiment it is essential, in order to ensure meaningful results, to start with a well-controlled chemical system. Coming after the chapter dealing with the requested care...
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Scale, the Local and Cultural Policy’s Geographies
David Bell and Lourdes Orozco introduce key debates in human geography about spatial scale and about the scale of the local, set in the context of cultural policy’s geographies. The chapter’s focus is on how d...
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Article
Prognostic factors and surgical outcomes of spontaneous spinal epidural haematoma: a systematic review and meta-analysis
Spontaneous spinal epidural haematoma (SSEH) is a rare disease defined as blood accumulation within the vertebral epidural space without a cause identified, which can lead to severe neurological deficits. We ...
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Article
Prognostic factors for surgically managed intramedullary spinal cord tumours: a single-centre case series
Intramedullary spinal cord tumours (IMSCTs) are comparatively rare neoplasms. We present a single-centre clinical case series of adult patients with surgically managed IMSCTs.
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Open AccessEvaluation of a haemozoin-based rapid diagnostic test for diagnosis of imported malaria during the phase of prevention of reestablishment in Sri Lanka
Sri Lanka, an island nation, has eliminated endemic malaria transmission. Maintaining elimination in the continued presence of vectors requires vigilance in screening people travelling from high malaria-risk a...
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Article
Open AccessEstimating female malaria mosquito age by quantifying Y-linked genes in stored male spermatozoa
Vector control strategies are among the most effective measures to combat mosquito-borne diseases, such as malaria. These strategies work by altering the mosquito age structure through increased mortality of t...
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Article
Open AccessRapid, sensitive, and low-cost detection of Escherichia coli bacteria in contaminated water samples using a phage-based assay
Inadequate drinking water quality is among the major causes of preventable mortality, predominantly in young children. Identifying contaminated water sources remains a significant challenge, especially where r...
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Article
Open AccessRisk-stratification of febrile African children at risk of sepsis using sTREM-1 as basis for a rapid triage test
Identifying febrile children at risk of sepsis in low-resource settings can improve survival, but recognition triage tools are lacking. Here we test the hypothesis that measuring circulating markers of immune ...
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Article
Open AccessPrediction of walking ability following posterior decompression for lumbar spinal stenosis
Following surgery for lumbar spinal stenosis (LSS) up to 40% of people report persistent walking disability. This study aimed to identify pre-operative factors that are predictive of walking ability post-surge...
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Article
Open AccessCorrection to: Refactoring of a synthetic raspberry ketone pathway with EcoFlex
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Open AccessRefactoring of a synthetic raspberry ketone pathway with EcoFlex
A key focus of synthetic biology is to develop microbial or cell-free based biobased routes to value-added chemicals such as fragrances. Originally, we developed the EcoFlex system, a Golden Gate toolkit, to ...
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Article
Open AccessA feasibility study evaluating a reservoir storage system for continuous oxygen delivery for children with hypoxemia in Kenya
Supplemental oxygen is an essential treatment for childhood pneumonia but is often unavailable in low-resource settings or unreliable due to frequent and long-lasting power outages. We present a novel medium p...
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Article
Open AccessPerformance of a fully‐automated system on a WHO malaria microscopy evaluation slide set
Manual microscopy remains a widely-used tool for malaria diagnosis and clinical studies, but it has inconsistent quality in the field due to variability in training and field practices. Automated diagnostic sy...
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Article
Open AccessNeurosurgery and coronavirus: impact and challenges—lessons learnt from the first wave of a global pandemic
The novel severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic has had drastic effects on global healthcare with the UK amongst the countries most severely impacted. The aim of this study was to...
