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  1. Article

    Open Access

    Non-linear Mendelian randomization: detection of biases using negative controls with a focus on BMI, Vitamin D and LDL cholesterol

    Mendelian randomisation (MR) is an established technique in epidemiological investigation, using the principle of random allocation of genetic variants at conception to estimate the causal linear effect of an ...

    Fergus W. Hamilton, David A. Hughes, Wes Spiller in European Journal of Epidemiology (2024)

  2. Article

    Open Access

    Genome-wide characterization of circulating metabolic biomarkers

    Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism17. This detailed knowledge of the genetic determinants of systemic me...

    Minna K. Karjalainen, Savita Karthikeyan, Clare Oliver-Williams, Eeva Sliz in Nature (2024)

  3. Article

    Open Access

    A genome-wide association study of neutrophil count in individuals associated to an African continental ancestry group facilitates studies of malaria pathogenesis

    'Benign ethnic neutropenia' (BEN) is a heritable condition characterized by lower neutrophil counts, predominantly observed in individuals of African ancestry, and the genetic basis of BEN remains a subject of...

    Andrei-Emil Constantinescu, David A. Hughes, Caroline J. Bull in Human Genomics (2024)

  4. Chapter

    Shock and Stress

    Ever since it became clear that victims of shell shock in World War I displayed increased psychological malleability, social engineers have sought to exploit the application of shock and stress for social cont...

    David A. Hughes in “Covid-19,” Psychological Operations, and the War for Technocracy (2024)

  5. Chapter

    Fear and Threat

    Western governments have long used manufactured fear as a means of kee** the population susceptible to propaganda. A “pandemic” is a powerful fear concept; yet, there is no credible evidence of a viral pande...

    David A. Hughes in “Covid-19,” Psychological Operations, and the War for Technocracy (2024)

  6. Chapter

    Weaponised Deception

    Totalitarianism is facilitated by calls “gigantic lies and monstrous falsehoods,” which the masses are organised to believe. This tradition has a long history, even in the West. The “Covid-19 pandemic” was a...

    David A. Hughes in “Covid-19,” Psychological Operations, and the War for Technocracy (2024)

  7. Chapter

    The Coming Unrest

    The transnational ruling class has no choice but to keep pushing for global technocracy, and the rest of humanity has no choice but to fight back. Knowing since 1968 at least that this moment was coming, the f...

    David A. Hughes in “Covid-19,” Psychological Operations, and the War for Technocracy (2024)

  8. Article

    Open Access

    The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT)

    High-throughput metabolomics technologies in a variety of study designs have demonstrated a consistent metabolomic signature of overweight and type 2 diabetes. However, the extent to which these metabolomic pa...

    Laura J. Corbin, David A. Hughes, Caroline J. Bull, Emma E. Vincent in Diabetologia (2024)

  9. Chapter

    Permanent Counterrevolution, Technocracy, and World War III

    An undeclared global class war was initiated in 2020, whose aim is the controlled demolition of liberal democracy and the institution of global technocracy—a novel, biodigital form of totalitarianism that thre...

    David A. Hughes in “Covid-19,” Psychological Operations, and the War for Technocracy (2024)

  10. Chapter

    Trauma-based Mind Control

    Increasing evidence has come to light of trauma-based mind exercises performed on children settings. Those exercises involve torture, near death experiences, and making victims feel responsible for the dea...

    David A. Hughes in “Covid-19,” Psychological Operations, and the War for Technocracy (2024)

  11. Chapter

    Cognitive Attack

    Menticide attacks the cognitive faculties of victims to break down their mental integrity and render them susceptible to indoctrination. During “Covid-19,” confusion was weaponised in various ways, including a...

    David A. Hughes in “Covid-19,” Psychological Operations, and the War for Technocracy (2024)

  12. Chapter

    Mass Paranoia and Hysteria: Turning Society Against Itself

    In kee** with totalitarianism, Covid-era psychological warfare worked to turn people against one another, to prevent them from uniting against their oppressors. Mass paranoia was inculcated through the lie t...

    David A. Hughes in “Covid-19,” Psychological Operations, and the War for Technocracy (2024)

  13. Book

  14. Article

    Open Access

    Using trials of caloric restriction and bariatric surgery to explore the effects of body mass index on the circulating proteome

    Thousands of proteins circulate in the bloodstream; identifying those which associate with weight and intervention-induced weight loss may help explain mechanisms of diseases associated with adiposity. We aime...

    Lucy J. Goudswaard, Madeleine L. Smith, David A. Hughes, Roy Taylor in Scientific Reports (2023)

  15. Article

    Open Access

    Author Correction: Application of Mendelian randomization to explore the causal role of the human gut microbiome in colorectal cancer

    Charlie Hatcher, George Richenberg, Samuel Waterson, Long H. Nguyen in Scientific Reports (2023)

  16. Article

    Open Access

    Application of Mendelian randomization to explore the causal role of the human gut microbiome in colorectal cancer

    The role of the human gut microbiome in colorectal cancer (CRC) is unclear as most studies on the topic are unable to discern correlation from causation. We apply two-sample Mendelian randomization (MR) to est...

    Charlie Hatcher, George Richenberg, Samuel Waterson, Long H. Nguyen in Scientific Reports (2023)

  17. Article

    Open Access

    A framework for research into continental ancestry groups of the UK Biobank

    The UK Biobank is a large prospective cohort, based in the UK, that has deep phenotypic and genomic data on roughly a half a million individuals. Included in this resource are data on approximately 78,000 indi...

    Andrei-Emil Constantinescu, Ruth E. Mitchell, Jie Zheng, Caroline J. Bull in Human Genomics (2022)

  18. Article

    Open Access

    Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates

    Variation in adiposity is associated with cardiometabolic disease outcomes, but mechanisms leading from this exposure to disease are unclear. This study aimed to estimate effects of body mass index (BMI) on an...

    Lucy J. Goudswaard, Joshua A. Bell, David A. Hughes in International Journal of Obesity (2021)

  19. No Access

    Article

    Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort

    Mutations in the melanocortin 4 receptor gene (MC4R) are associated with obesity but little is known about the prevalence and impact of such mutations throughout human growth and development. We examined the MC4R

    Kaitlin H. Wade, Brian Y. H. Lam, Audrey Melvin, Warren Pan in Nature Medicine (2021)

  20. Article

    Open Access

    Variation of microRNA expression in the human placenta driven by population identity and sex of the newborn

    Analysis of lymphocyte cell lines revealed substantial differences in the expression of mRNA and microRNA (miRNA) among human populations. The extent of such population-associated differences in actual human t...

    Song Guo, Shuyun Huang, ** Jiang, Haiyang Hu, Dingding Han in BMC Genomics (2021)

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