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Reference Work Entry In depth
Glanders and Melioidosis: A Zoonosis and a Sapronosis
, caused by infection with Burkholderia mallei, primarily causes infection in , but may be transmitted to humans, and thus qualifies as a true zoonosis. Melioidosis is caused by , genetically very similar to B....
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Article
Open AccessA novel lytic phage potentially effective for phage therapy against Burkholderia pseudomallei in the tropics
Burkholderia pseudomallei is a tropical pathogen that causes melioidosis. Its intrinsic drug-resistance is a leading cause of treatment failure, and the few available antibiotics require prolonged use to be effec...
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Article
Open AccessDistribution of Burkholderia pseudomallei within a 300-cm deep soil profile: implications for environmental sampling
The environmental distribution of Burkholderia pseudomallei, the causative agent of melioidosis, remains poorly understood. B. pseudomallei is known to have the ability to occupy a variety of environmental niches...
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Living Reference Work Entry In depth
Glanders & Melioidosis - A Zoonosis and a Sapronosis
, caused by infection with Burkholderia mallei, primarily causes infection in , but may be transmitted to humans, and thus qualifies as a true zoonosis. Melioidosis is caused by , genetically very similar to B....
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Article
Open AccessEvolutionary histories and antimicrobial resistance in Shigella flexneri and Shigella sonnei in Southeast Asia
Conventional disease surveillance for shigellosis in develo** country settings relies on seroty** and low-resolution molecular ty**, which fails to contextualise the evolutionary history of the genus. He...
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Article
Open AccessImpact of delays to incubation and storage temperature on blood culture results: a multi-centre study
Blood cultures are one of the most important tests performed by microbiology laboratories. Many hospitals, particularly in low and middle-income countries, lack either microbiology services or staff to provide...
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Article
Open AccessMyanmar Burkholderia pseudomallei strains are genetically diverse and originate from Asia with phylogenetic evidence of reintroductions from neighbouring countries
Melioidosis was first identified in Myanmar in 1911 but for the last century it has remained largely unreported there. Burkholderia pseudomallei was first isolated from the environment of Myanmar in 2016, confirm...
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Article
Open AccessGenomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia
Klebsiella pneumoniae is a leading cause of bloodstream infection (BSI). Strains producing extended-spectrum beta-lactamases (ESBLs) or carbapenemases are considered global priority pathogens for which new treatm...
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Article
Open AccessThe global impact and cost-effectiveness of a melioidosis vaccine
Every year, 90,000 people may die from melioidosis. Vaccine candidates have not proceeded past animal studies, partly due to uncertainty around the potential market size. This study aims to estimate the potent...
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Article
Open AccessMicrobiology Investigation Criteria for Reporting Objectively (MICRO): a framework for the reporting and interpretation of clinical microbiology data
There is a pressing need to understand better the extent and distribution of antimicrobial resistance on a global scale, to inform development of effective interventions. Collation of datasets for meta-analysi...
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Article
Open AccessRivers as carriers and potential sentinels for Burkholderia pseudomallei in Laos
Burkholderia pseudomallei, causative agent of the often fatal disease melioidosis, dwells in tropical soils and has been found in freshwater bodies. To investigate whether rivers are potential habitats or carrier...
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Article
Melioidosis
Burkholderia pseudomallei is a Gram-negative environmental bacterium and the aetiological agent of melioidosis, a life-threatening infection that is estimated to account for ∼89,000 deaths per year worldwide. Dia...
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Article
Open AccessClostridium difficile infection in the Lao People’s Democratic Republic: first isolation and review of the literature
Current knowledge of the epidemiology of Clostridium difficile infection in Asia, and in particular the Greater Mekong Subregion, is very limited. Only a few studies from Thailand and Vietnam have been reported f...
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Article
Open AccessAcute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus
The Human respiratory syncytial virus (RSV) is one of the most important viral pathogens, causing epidemics of acute respiratory infection (ARI), especially bronchiolitis and pneumonia, in children worldwide. To ...
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Article
Global and regional dissemination and evolution of Burkholderia pseudomallei
The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B...
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Article
Open AccessA retrospective analysis of melioidosis in Cambodian children, 2009–2013
Melioidiosis, infection by Burkholderia pseudomallei, is an important but frequently under-recognised cause of morbidity and mortality in Southeast Asia and elsewhere in the tropics. Data on the epidemiology of p...
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Article
Open AccessLand use and soil type determine the presence of the pathogen Burkholderia pseudomallei in tropical rivers
Burkholderia pseudomallei is the bacterium that causes melioidosis in humans. While B. pseudomallei is known to be endemic in South East Asia (SEA), the occurrence of the disease in other...
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Article
Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis
Burkholderia pseudomallei, a highly pathogenic bacterium that causes melioidosis, is commonly found in soil in Southeast Asia and Northern Australia1,2. Melioidosis can be difficult to diagnose due to its diverse...
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Chapter
Melioidosis in Laos
Melioidosis is a serious infectious tropical disease caused by a soil-dwelling bacterium, Burkholderia pseudomallei, transmitted from contaminated soil or surface water. Although endemic in Southeast Asia, it is ...
