9 Result(s)
within
Darren C. Henstridge
Science, Humanities and Social Sciences, multidisciplinary
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Article
Author Correction: Sex-specific adipose tissue imprinting of regulatory T cells
A Correction to this paper has been published: https://doi.org/10.1038/s41586-020-2251-7
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Open AccessDeletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance
The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have been implicated in WAT lipid metabolism, including tripartite motif containing 28 (T...
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Sex-specific adipose tissue imprinting of regulatory T cells
Adipose tissue is an energy store and a dynamic endocrine organ1,2. In particular, visceral adipose tissue (VAT) is critical for the regulation of systemic metabolism3,4. Impaired VAT function—for example, in obe...
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Treatment of type 2 diabetes with the designer cytokine IC7Fc
The gp130 receptor cytokines IL-6 and CNTF improve metabolic homeostasis but have limited therapeutic use for the treatment of type 2 diabetes. Accordingly, we engineered the gp130 ligand IC7Fc, in which one g...
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Open AccessCorrection: Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
Nature Communications 7: Article number: 12862 (2016); Published: 27 September 2016; Updated: 30 August 2017 In Supplementary Fig. 7 of this Article, graphs presenting 6-PFK kinetics in panel d were inadverten...
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Open AccessMuscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects
Hypoadiponectinemia and adiponectin resistance are implicated in the aetiology of obesity-related cardiometabolic disorders, hence represent a potential therapeutic axis. Here we characterised the effects of in v...
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Open Access14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
The 14-3-3 family of adaptor proteins regulate diverse cellular functions including cell proliferation, metabolism, adhesion and apoptosis. Platelets express numerous 14-3-3 isoforms, including 14-3-3ζ, which ...
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The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice
Heart failure (HF) and atrial fibrillation (AF) share common risk factors, frequently coexist and are associated with high mortality. Treatment of HF with AF represents a major unmet need. Here we show that a ...
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Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
Increasing the expression of intramuscular heat shock protein 72 preserves muscle strength and ameliorates the dystrophic pathology in two mouse models of muscular dystrophy, suggesting a promising way forward...
