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  1. Article

    Open Access

    Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity

    Lipotoxicity, the accumulation of lipids in non-adipose tissues, alters the metabolic transcriptome and mitochondrial metabolism in skeletal muscle. The mechanisms involved remain poorly understood. Here we sh...

    Sheree D. Martin, Timothy Connor, Andrew Sanigorski… in Cell Death & Disease (2023)

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    Article

    MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3+ regulatory T cells

    FOXP3+ regulatory T (Treg) cells are essential for maintaining immunological tolerance. Given their importance in immune-related diseases, cancer and obesity, there is increasing interest in targeting the Treg ce...

    Charis E. Teh, Alissa K. Robbins, Darren C. Henstridge… in Cell Death & Differentiation (2020)

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    Article

    Genetic manipulation of cardiac Hsp72 levels does not alter substrate metabolism but reveals insights into high-fat feeding-induced cardiac insulin resistance

    Heat shock protein 72 (Hsp72) protects cells against a variety of stressors, and multiple studies have suggested that Hsp72 plays a cardioprotective role. As skeletal muscle Hsp72 overexpression can protect ag...

    Darren C. Henstridge, E. Estevez, T. L. Allen, S. E. Heywood… in Cell Stress and Chaperones (2015)