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Article
Efficacy of chidamide maintenance therapy versus autologous stem cell transplantation versus observation as a post-remission choice in the survival of adult patients with peripheral T-cell lymphoma: Post hoc analysis of a prospective, multicenter, phase 2 study in China
In this prospective, multicenter, Phase 2 clinical trial (NCT02987244), patients with peripheral T-cell lymphomas (PTCLs) who had responded to first-line chemotherapy with cyclophosphamide, doxorubicin or epir...
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Article
Performance evaluation of underground pipelines subjected to landslide thrust with fiber optic strain sensing nerves
High-accuracy deformation monitoring is crucial for investigating landslide–pipeline interaction problems, in which the fiber optic nerve system (FONS) holds enormous potential. This paper presents a theoretic...
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Article
Open AccessCritically ill children with SARS-COV-2 Omicron infection at a national children medical center, Guangdong, China
SARS-CoV-2 infection is described as asymptomatic, mild, or moderate disease in most children. SARS-CoV-2 infection related death in children and adolescents is rare according to the current reports. COVID-19 ...
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Article
Open AccessDNA methylation remodeling and the functional implication during male gametogenesis in rice
Epigenetic marks are reprogrammed during sexual reproduction. In flowering plants, DNA methylation is only partially remodeled in the gametes and the zygote. However, the timing and functional significance of ...
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Article
PCA-VGG16 model for classification of rock types
Conventional convolutional neural networks (CNN) are deficient in the rock type recognition due to large convolutional kernels and numerous network parameters necessitated for recognition of complex images. Th...
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Article
A multi-parameter intrahepatic cholangiocarcinoma scoring system based on modified contrast-enhanced ultrasound LI-RADS M criteria for differentiating intrahepatic cholangiocarcinoma from hepatocellular carcinoma
To develop a multi-parameter intrahepatic cholangiocarcinoma (ICC) scoring system and compare its diagnostic performance with contrast-enhanced ultrasound (CEUS) liver imaging reporting and data system M (LR-M...
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Article
Open AccessThe prevention of rectovaginal fistula after rectal cancer surgery by packing with laparoscopic dislocated fat flap containing ovarian vascular pedicle anterior to the anastomotic stoma: a parallel group randomized controlled trial protocol
Rectovaginal fistula (RVF) is an abnormal channel formed by epithelial tissue between the anterior wall of the rectum and the posterior wall of the vagina, which manifests as vaginal gassing and defecation. It...
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Article
Network pharmacology-based approach to understand the effect and mechanism of chrysophanol against cognitive impairment in Wilson disease
Wilson disease (WD) is a rare hereditary copper metabolism disorder, wherein cognitive impairment is a common clinical symptom. Chrysophanol (CHR) is an active compound with neuroprotective effects. The study ...
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Article
Open AccessGut microbial structural variation associates with immune checkpoint inhibitor response
The gut microbiota may have an effect on the therapeutic resistance and toxicity of immune checkpoint inhibitors (ICIs). However, the associations between the highly variable genomes of gut bacteria and the ef...
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Article
Open AccessGut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways
Although the gut microbiota has been reported to influence osteoporosis risk, the individual species involved, and underlying mechanisms, remain largely unknown. We performed integrative analyses in a Chinese ...
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Article
Casticin Attenuates Stemness in Cervical Cancer Stem-Like Cells by Regulating Activity and Expression of DNMT1
To explore whether casticin (CAS) suppresses stemness in cancer stem-like cells (CSLCs) obtained from human cervical cancer (CCSLCs) and the underlying mechanism.
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Article
Differentiating Follicular Thyroid Carcinoma and Thyroid Adenoma by Using Near-Infrared Surface-Enhanced Raman Spectroscopy
We aimed to identify the differentially expressed molecules in the serum and neoplastic tissue of patients with follicular thyroid carcinoma (FTC) and thyroid adenoma (TA) by using near-infrared surface-enhanc...
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Article
Open AccessEffect of alendronate sodium plus vitamin D3 tablets on knee joint structure and osteoarthritis pain: a multi-center, randomized, double-blind, placebo-controlled study protocol
Osteoarthritis (OA) is a major cause of pain and disability worldwide. Despite the relatively high burden of the disease, the currently available non-surgical treatment options are directed towards symptomatic...
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Article
Preoperative combination score of neutrophils, monocytes, and lymphocytes as a predictor for locally advanced rectal cancer
The aim of this study was to investigate the prognostic value of baseline peripheral blood neutrophils, monocytes, and lymphocytes on locally advanced rectal cancer (LARC) patients.
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Article
Noninvasive evaluation of hypoxia in rabbit VX2 lung transplant tumors using spectral CT parameters and texture analysis
Noninvasive evaluation of hypoxia in rabbit VX2 lung transplant tumors using spectral CT parameters and texture analysis.
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Article
Long Slimmer Metal Stent Is Feasible and Effective for Endoscopic Dual Stent-by-Stent Placement in Malignant Hilar Biliary Stricture
Bilateral endoscopic biliary stenting remains technically challenging, which limits its wider clinical application.
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Article
Open AccessAssociation between HLA alleles and sub-phenotype of childhood steroid-sensitive nephrotic syndrome
Few studies have addressed the effects of human leukocyte antigen (HLA) alleles on different clinical sub-phenotypes in childhood steroid-sensitive nephrotic syndrome (SSNS), including SSNS without recurrence ...
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Article
Open AccessA reverse transcription-cross-priming amplification method with lateral flow dipstick assay for the rapid detection of Bean pod mottle virus
Bean pod mottle virus (BPMV) is a destructive virus that causes serious economic losses in many countries every year, highlighting the importance of its effective detection. In this study, we developed a fast rev...
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Article
Sliding wear behaviour of Fe/316L/430-Ti(C,N) composites prepared via spark plasma sintering and subsequent heat treatment
A series of novel steel-Ti(C,N) composites was fabricated by spark plasma sintering (SPS) and subsequent heat treatment. The hardness, indentation fracture resistance, and wear behaviour of the steel-Ti(C,N) c...
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Article
Distinguishing Rectal Cancer from Colon Cancer Based on the Support Vector Machine Method and RNA-sequencing Data
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. Several studies have indicated that rectal cancer is significantly different from colon cancer in terms of treatment, prognosis, a...
