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  1. Article

    Open Access

    C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome

    Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT). However...

    Danyu You, Kun Nie, **aoting Wu, Mengjie Weng… in Journal of Translational Medicine (2023)

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  2. No Access

    Article

    Knockout of the C3a receptor protects against renal ischemia reperfusion injury by reduction of NETs formation

    Renal ischemia/reperfusion (I/R) injury is a local sterile inflammatory response driven by innate immunity. Emerging data have revealed that complement and neutrophils contribute to hyperinflammation and oxida...

    **aoting Wu, Danyu You, Maoen Pan, Mengjie Weng… in Cellular and Molecular Life Sciences (2023)

  3. No Access

    Article

    Role of Complement 3 in TNF-α-Induced Mesenchymal Transition of Renal Tubular Epithelial Cells In Vitro

    Injured renal tubular epithelial cells (RTECs) have been recently thought to directly contribute to the accumulation of myofibroblasts in renal tubulointerstitial fibrosis through a process of epithelial to me...

    Jianxin Wan, Xueli Zhou, Jiong Cui, Zhenhuan Zou, Yanfang Xu… in Molecular Biotechnology (2013)