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  1. Article

    Open Access

    Lovastatin inhibits erythroleukemia progression through KLF2-mediated suppression of MAPK/ERK signaling

    Lovastatin, an HMG-CoA inhibitor and an effective cholesterol lowering drug, exhibits anti-neoplastic activity towards several types of cancer, although the underlying mechanism is still not fully understood. ...

    Jian Gao, Jifen Hu, Fang Yu, Chunlin Wang, Danmei Sheng, Wuling Liu… in BMC Cancer (2023)

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    Article

    FLI1 accelerates leukemogenesis through transcriptional regulation of pyruvate kinase-L/R and other glycolytic genes

    In cancer cells, multiple oncogenes and tumor suppressors control glycolysis to sustain rapid proliferation. The ETS-related transcription factor Fli1 plays a critical role in the induction and progression of ...

    Danmei Sheng, Beiling Chen, Chunlin Wang, **ao **ao, Anling Hu… in Medical Oncology (2022)