-
Article
Open AccessSex differences in trajectories of cortical development in autistic children from 2–13 years of age
Previous studies have reported alterations in cortical thickness in autism. However, few have included enough autistic females to determine if there are sex specific differences in cortical structure in autism...
-
Article
Open AccessAssociation of Breastfeeding Duration with Neurodevelopmental Outcomes in an Enriched Familial Likelihood Cohort for Autism Spectrum Disorder
This study aimed to compare the breastfeeding (BF) duration of the younger siblings of children with ASD in an enriched-likelihood cohort for autism spectrum disorder (ASD), and to determine whether longer BF ...
-
Article
Open AccessNon-invasive quantification of 18F-florbetaben with total-body EXPLORER PET
Kinetic modeling of 18F-florbetaben provides important quantification of brain amyloid deposition in research and clinical settings but its use is limited by the requirement of arterial blood data for quantitativ...
-
Article
Open AccessExpressive language sampling and outcome measures for treatment trials in fragile X and down syndromes: composite scores and psychometric properties
The lack of psychometrically sound outcome measures has been a barrier to evaluating the efficacy of treatments proposed for core symptoms of intellectual disability (ID). Research on Expressive Language Sampl...
-
Article
Open AccessTranscriptomic and glycomic analyses highlight pathway-specific glycosylation alterations unique to Alzheimer’s disease
Glycosylation has been found to be altered in the brains of individuals with Alzheimer’s disease (AD). However, it is unknown which specific glycosylation-related pathways are altered in AD dementia. Using pub...
-
Article
Open AccessDietary inflammatory index and cardiovascular disease risk in Hispanic women from the Women’s Health Initiative
To evaluate the association between the dietary inflammatory index (DII®) and incident cardiovascular disease (CVD) in Hispanic women from the Women’s Health Initiative (WHI), and to determine if body mass index ...
-
Article
Open AccessRelationship between Apgar scores and long-term cognitive outcomes in individuals with Down syndrome
This study examined the contribution of the Apgar score at 1 and 5 min after birth to later cognitive functioning in 168 individuals with Down syndrome who were between 6 and 25 years of age at time of cogniti...
-
Article
Lipidomic Analysis of Postmortem Prefrontal Cortex Phospholipids Reveals Changes in Choline Plasmalogen Containing Docosahexaenoic Acid and Stearic Acid Between Cases With and Without Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive and incurable brain disorder that has been associated with structural changes in brain phospholipids (PLs), including diacyl species and ether-linked PLs known as plas...
-
Article
The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity
Organophosphate (OP) threat agents can trigger seizures that progress to status epilepticus, resulting in persistent neuropathology and cognitive deficits in humans and preclinical models. However, it remains unc...
-
Article
Open AccessAcute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain
Neuroinflammation can modulate brain development; however, the influence of an acute peripheral immune challenge on neuroinflammatory responses in the early postnatal brain is not well characterized. To addres...
-
Article
ASD Comorbidity in Fragile X Syndrome: Symptom Profile and Predictors of Symptom Severity in Adolescent and Young Adult Males
Many males with FXS meet criteria for ASD. This study was designed to (1) describe ASD symptoms in adolescent and young adult males with FXS (n = 44) and (2) evaluate the contributions to ASD severity of cognitiv...
-
Article
Open AccessThe risk and burden of smoking related heart disease mortality among young people in the United States
Although cigarette smoking remains the most common risk factor for heart disease among the young, few studies have explored the relationship of smoking with heart disease mortality risk among young people. Thi...
-
Article
Association between high-sensitivity C-reactive protein (hsCRP) and change in mammographic density over time in the SWAN mammographic density subcohort
High mammographic density (MD) is a strong risk factor for breast cancer. Chronic inflammation may be related to breast cancer risk through a mechanism involving the percent of breast area that is dense (perce...
-
Article
Open AccessCommon and specific impairments in attention functioning in girls with chromosome 22q11.2 deletion, fragile X or Turner syndromes
Chromosome 22q11.2 deletion syndrome (22q11.2DS), fragile X syndrome (FXS), and Turner syndrome (TS) are complex and variable developmental syndromes caused by different genetic abnormalities; yet, they share ...
-
Article
Open AccessA cross-sectional study of the development of volitional control of spatial attention in children with chromosome 22q11.2 deletion syndrome
Chromosome 22q11.2 deletion syndrome (22q11.2DS) results from a 1.5- to 3-megabase deletion on the long arm of chromosome 22 and occurs in approximately 1 in 4000 live births. Previous studies indicate that ch...
-
Article
Open AccessA new implicit review instrument for measuring quality of care delivered to pediatric patients in the emergency department
There are few outcomes experienced by children receiving care in the Emergency Department (ED) that are amenable to measuring for the purposes of assessing of quality of care. The purpose of this study was to ...
