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Article
Open AccessMachine learning for exploring neurophysiological functionality in multiple sclerosis based on trigeminal and hand blink reflexes
Brainstem dysfunctions are very common in Multiple Sclerosis (MS) and are a critical predictive factor for future disability. Brainstem functionality can be explored with blink reflexes, subcortical responses ...
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Article
Open AccessA multi-expert ensemble system for predicting Alzheimer transition using clinical features
Alzheimer’s disease (AD) diagnosis often requires invasive examinations (e.g., liquor analyses), expensive tools (e.g., brain imaging) and highly specialized personnel. The diagnosis commonly is established wh...
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Article
Open AccessMachine Learning analysis of high-grade serous ovarian cancer proteomic dataset reveals novel candidate biomarkers
Ovarian cancer is one of the most common gynecological malignancies, ranking third after cervical and uterine cancer. High-grade serous ovarian cancer (HGSOC) is one of the most aggressive subtype, and the lat...
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Chapter
A Computational Hypothesis on How Serotonin Regulates Catecholamines in the Pathogenesis of Depressive Apathy
Despite increasing literature supports a strong involvement of dopamine, noradrenaline and serotonin dysfunctions in the pathogenesis of most depressive disorders, the (causal) relationship between those monoa...
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Article
Open AccessConsensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex
Despite increasing evidence suggesting the cerebellum works in concert with the cortex and basal ganglia, the nature of the reciprocal interactions between these three brain regions remains unclear. This conse...
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Article
Open AccessParkinson’s disease as a system-level disorder
Traditionally, the basal ganglia have been considered the main brain region implicated in Parkinson’s disease. This single area perspective gives a restricted clinical picture and limits therapeutic approaches...
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Article
Transitional Wearable Companions: A Novel Concept of Soft Interactive Social Robots to Improve Social Skills in Children with Autism Spectrum Disorder
We present a novel concept of interactive devices, called “transitional wearable companions” (TWCs), usable to support therapy and foster social skill development in children with autism spectrum disorder (ASD...
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Article
Vision, action and language unified through embodiment
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Article
How affordances associated with a distractor object affect compatibility effects: A study with the computational model TRoPICALS
Seeing an object activates both visual and action codes in the brain. Crucial evidence supporting this view is the observation of object to response compatibility effects: perception of an object can facilitat...
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Chapter
The Hierarchical Organisation of Cortical and Basal-Ganglia Systems: A Computationally-Informed Review and Integrated Hypothesis
To suitably adapt to the challenges posed by reproduction and survival, animals need to learn to select when to perform different behaviours, to have internal criteria for guiding these learning processes, and...
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Chapter
Objects, Words and Actions: Some Reasons Why Embodied Models are Badly Needed in Cognitive Psychology
In the present chapter we report experiments on the relationships between visual objects and action and between words and actions. Results show that seeing an object activates motor information and that langua...
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Chapter and Conference Paper
Some Adaptive Advantages of the Ability to Make Predictions
We describe some simple simulations showing two possible adaptive advantages of the ability to predict the consequences of one’s actions: predicted inputs can replace missing inputs and predicted success vs. f...
