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Article
Open AccessRuxolitinib for the treatment of acute graft-versus-host disease: a retrospective analysis
Steroid-refractory acute graft-versus-host disease (aGvHD) is a serious complication after allogeneic hematopoietic stem cell transplantation, associated with significant mortality. Ruxolitinib was the first d...
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Article
Open AccessEfficacy and safety of ruxolitinib in the treatment of chronic graft-versus-host disease: a retrospective analysis
Steroid-refractory chronic graft-versus-host disease (cGvHD) is associated with significant morbidity and mortality, with ruxolitinib being the first drug approved for its treatment. We retrospectively analyze...
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Article
Open AccessInformal and formal long-term care utilization and unmet needs in Europe: examining socioeconomic disparities and the role of social policies for older adults
The rising number of older adults with limitations in their daily activities has major implications for the demands placed on long-term care (LTC) systems across Europe. Recognizing that demand can be both con...
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Article
Clinical evaluation of complete remission (CR) with partial hematologic recovery (CRh) in acute myeloid leukemia: a report of 7235 patients from seven cohorts
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Article
Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation
The microbiome is a predictor of clinical outcome in patients receiving allogeneic hematopoietic stem cell transplantation (allo-SCT). Microbiota-derived metabolites can modulate these outcomes. How bacteria, ...
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Article
Open AccessAML consolidation therapy: timing matters
Infections due to severe neutropenia are the most common therapy-associated causes of mortality in patients with acute myeloid leukemia (AML). New strategies to lessen the severity and duration of neutropenia ...
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Article
Open AccessCirculating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics
Circulating cell-free DNA (cf-DNA) has emerged as a promising biomarker of ageing, tissue damage and cellular stress. However, less is known about health behaviours, ageing phenotypes and metabolic processes t...
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Article
Open AccessDetrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle
Current data regarding the roles of branched-chain amino acids (BCAA) in metabolic health are rather conflicting, as positive and negative effects have been attributed to their intake.
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Article
Open AccessLive longer, retire later? Developments of healthy life expectancies and working life expectancies between age 50–59 and age 60–69 in Europe
Europe’s population is ageing. Statutory retirement ages are commonly raised to account for continuous increases in life expectancy. In order to estimate the potential to increase statutory and consequently ef...
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Article
A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts
Phenotype-specific omic expression patterns in people with frailty could provide invaluable insight into the underlying multi-systemic pathological processes and targets for intervention. Classical approaches ...
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Article
Open AccessAbatacept as salvage therapy in chronic graft-versus-host disease—a retrospective analysis
The immunomodulatory fusion protein abatacept has recently been investigated for the treatment of steroid-refractory chronic graft-versus-host disease (cGvHD) in a phase 1 clinical trial. We analyzed the safet...
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Article
Open Access1,25-dihydroxyvitamin-D3 but not the clinically applied marker 25-hydroxyvitamin-D3 predicts survival after stem cell transplantation
The serum level of 25-hydroxyvitamin-D3 is accepted as marker for a person’s vitamin D status but its role for the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) is controversially discus...
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Article
Open AccessCyclophosphamide for salvage therapy of chronic graft-versus-host disease: a retrospective analysis
We retrospectively analyzed the safety and efficacy of cyclophosphamide (cyclo) for salvage treatment of chronic graft-versus-host disease (cGvHD) and cGvHD-associated (glomerulo-)nephritis at our center betwe...
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Article
Open AccessProspects of activity limitations among older adults in 23 low and middle income countries
Increasing life expectancy and a growing share of older people around the world spotlight the issue of health during additional years of life. Research on trends of proportions of older people with activity li...
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Article
Open AccessPlant resistance does not compromise parasitoid-based biocontrol of a strawberry pest
Plant nutritional quality can influence interactions between herbivores and their parasitoids. While most previous work has focused on a limited set of secondary plant metabolites, the tri-trophic effects of ...
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Article
Open AccessIL6-receptor antibody tocilizumab as salvage therapy in severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a retrospective analysis
Chronic graft-versus-host disease (cGvHD) remains the most relevant factor affecting survival after allogeneic hematopoietic stem cell transplantation (alloHSCT). Besides corticosteroids (and ibrutinib in the ...
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Article
Open AccessFunctional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML)
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Article
Open AccessGenetic variation in herbivore resistance within a strawberry crop wild relative (Fragaria vesca L.)
To decrease the dependency on chemical pesticides, the resistance of cultivated strawberry to pests needs to be increased. While genetic resources within domesticated varieties are limited, wild genotypes are ...
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Article
Open AccessFunctional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1)
BRCA1/BRCA2-containing complex 3 (BRCC3) is a Lysine 63-specific deubiquitinating enzyme (DUB) involved in inflammasome activity, interferon signaling, and DNA damage repair. Recurrent mutations in BRCC3 have bee...
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Combining Working Life and Health Expectancies
People around the world are living longer while fertility has been declining in the great majority of countries. Increasing the length of working lives is a commonly sought remedy to deal, at least in part, wi...
