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11 Result(s)

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  1. No Access

    Article

    Up-regulation of HIF-1α is associated with neuroprotective effects of agmatine against rotenone-induced toxicity in differentiated SH-SY5Y cells

    Agmatine, a metabolite generated by arginine decarboxylation, has been reported as neuromodulator and neuroactive substance. Several findings suggest that agmatine displays neuroprotective effects in several m...

    Nadia Ferlazzo, Monica Currò, Maria Laura Giunta, Domenico Longo… in Amino Acids (2020)

  2. No Access

    Article

    Transglutaminase 2 is involved in amyloid-beta1–42-induced pro-inflammatory activation via AP1/JNK signalling pathways in THP-1 monocytes

    Deposition of amyloid-beta (Aβ) peptides has been shown to induce the release of inflammatory factors by activated microglia and brain infiltrating monocytes/macrophages. Interestingly, the enzyme transglutami...

    Monica Currò, Chiara Gangemi, Maria Laura Giunta, Nadia Ferlazzo… in Amino Acids (2017)

  3. No Access

    Article

    Transglutaminase 2 up-regulation is associated with RANKL/OPG pathway in cultured HPDL cells and THP-1-differentiated macrophages

    Recent evidence emphasized that transglutaminase 2 (TG2), a protein cross-linking enzyme, may play a role in the early phase of inflammation. High levels of TG2 have been associated with the constitutive activ...

    Giovanni Matarese, Monica Currò, Gaetano Isola, Daniela Caccamo… in Amino Acids (2015)

  4. No Access

    Article

    Transglutaminase 2 and neuroinflammation

    Neuroinflammatory processes seem to play a pivotal role in various chronic neurodegenerative diseases, characterized also by the pathogenetic accumulation of specific protein aggregates. Several of these prote...

    Riccardo Ientile, Monica Currò, Daniela Caccamo in Amino Acids (2015)

  5. No Access

    Article

    Transglutaminase 2 and phospholipase A2 interactions in the inflammatory response in human Thp-1 monocytes

    Several experimental approaches have demonstrated that transglutaminase 2 (TG2) increased activity is involved in monocyte activation and inflammatory response. Preliminary results also demonstrate a TG-mediat...

    Monica Currò, Nadia Ferlazzo, Roberto Risitano, Salvatore Condello… in Amino Acids (2014)

  6. No Access

    Article

    Transglutaminase 2 interaction with small heat shock proteins mediate cell survival upon excitotoxic stress

    Transglutaminase 2 has been postulated to be involved in the pathogenesis of central nervous system neurodegenerative disorders. However, its role in neuronal cell death remains to be elucidated. Excitotoxicit...

    Daniela Caccamo, Salvatore Condello, Nadia Ferlazzo, Monica Currò… in Amino Acids (2013)

  7. No Access

    Article

    Monitoring of transglutaminase2 under different oxidative stress conditions

    Transglutaminase 2 (TG2) is a multifunctional calcium-dependent enzyme which catalyzes the post-translational protein crosslinking with formation of intra- or inter-molecular epsilon(gamma-glutamyl)lysine bond...

    Daniela Caccamo, Monica Currò, Nadia Ferlazzo, Salvatore Condello… in Amino Acids (2012)

  8. No Access

    Article

    Protective effects of agmatine in rotenone-induced damage of human SH-SY5Y neuroblastoma cells: Fourier transform infrared spectroscopy analysis in a model of Parkinson’s disease

    Agmatine is a novel neuromodulator that plays a protective role in the CNS in several models of cellular damage. However, the mechanisms involved in these protective effects in neurodegenerative diseases are p...

    Salvatore Condello, Emanuele Calabrò, Daniela Caccamo, Monica Currò… in Amino Acids (2012)

  9. No Access

    Article

    Transglutaminase 2 silencing reduced the beta-amyloid-effects on the activation of human THP-1 cells

    The aberrant expression and activation of transglutaminase 2 (TG2), the ubiquitous enzyme which catalyzes calcium-dependent protein cross-linking reactions, has been reported in many inflammatory diseases. Chr...

    Monica Currò, Nadia Ferlazzo, Salvatore Condello, Daniela Caccamo… in Amino Acids (2010)

  10. No Access

    Article

    Critical role of transglutaminase and other stress proteins during neurodegenerative processes

    Proteolytic stress, resulting from the intracellular accumulation of misfolded or aggregated proteins, which exceed the capacity of the ubiquitin–proteasome system to degrade them, plays a relevant role in neu...

    Daniela Caccamo, Monica Currò, Salvatore Condello, Nadia Ferlazzo… in Amino Acids (2010)

  11. No Access

    Article

    Expression pattern of transglutaminases in the early differentiation stage of erupting rat incisor

    Several studies demonstrated that transglutaminases play a key role in extracellular matrix stabilization needed for cell differentiation. We evaluated transglutaminase expression and activity in the pre-secre...

    Daniela Caccamo, Debora Di Mauro, Salvatore Condello, Monica Currò… in Amino Acids (2009)