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Open AccessClinical impact of EZH2 and its antagonist SMARCA4 in ovarian cancer
SMARCA4 and EZH2 are two functional key players of their respective antagonizing chromatin remodeling complexes SWI/SNF and PRC2. EZH2 inhibitory drugs may abrogate pro-oncogenic features of PRC2 and turn the ...
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Article
Open AccessPARP inhibitors in the treatment of ovarian cancer
The recent exciting findings on the use of poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitor (PARPi) maintenance therapy in the first-line and later lines of treatment in ovarian cancer are illustr...
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Ovarian Cancer Stem Cell Heterogeneity
Ovarian carcinoma features pronounced clinical, histopathological, and molecular heterogeneity. There is good reason to believe that parts of this heterogeneity can be explained by differences in the respectiv...
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Article
Open AccessEvaluation of Vav3.1 as prognostic marker in endometrial cancer
Vav3 is a guanine nucleotide exchange factor that regulates the activity of Rho/Rac family GTPases. In a study on ovarian cancer, we recently demonstrated pronounced prognostic and predictive value of Vav3.1, ...
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Article
Open AccessPrognostic role of plasma fibrinogen in patients with uterine leiomyosarcoma – a multicenter study
Fibrinogen has an important pathophysiological role in tumor cell progression and development of metastases in different types of cancer. The present study aimed to evaluate the role of pre-treatment fibrinoge...
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Open AccessEvaluation of folate receptor 1 (FOLR1) mRNA expression, its specific promoter methylation and global DNA hypomethylation in type I and type II ovarian cancers
In this retrospective study we evaluated the respective correlations and clinical relevance of FOLR1 mRNA expression, FOLR1 promoter specific methylation and global DNA hypomethylation in type I and type II ov...
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Open AccessExpression and promotor hypermethylation of miR-34a in the various histological subtypes of ovarian cancer
An increasing body of evidence shows that miR-34 family has tumor suppressive properties mediating apoptosis, cell cycle arrest and senescence. In ovarian cancer, miR34 family members were found to be under ex...
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Article
Sustainability in the Field: Lake Tahoe Hospitality and Environmental Protection
The Embassy Suites Lake Tahoe, a Hilton Corporation hotel located in South Lake Tahoe, California, is working to become an environmentally responsible lodging business. This case study describes what the site ...
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Article
Open AccessFatal invasive cervical cancer secondary to untreated cervical dysplasia: a case report
Well-documented cases of untreated cervical intra-epithelial dysplasia resulting in fatal progression of invasive cervical cancer are scarce because of a long pre-invasive state, the availability of cervical c...
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Article
Urinary neopterin does not reflect the local antitumor immune milieu in ovarian cancer
The main objective of the present investigation was to study the urinary neopterin excretion in the context of the activation of the adaptive cellular immune system at the tumor site. For this purpose, we comp...
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Expression of coxsackie-adenovirus receptor is related to estrogen sensitivity in breast cancer
This study analyzes the relationship between coxsackie-adenovirus receptor (CAR) expression (transmembrane and soluble isoforms) and hormone sensitivity in 95 breast cancers. Furthermore, prognostic significan...
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Disturbed atrio-ventricular conduction and normal contractile function in isolated hearts from Cav1.3-knockout mice
Cardiac L-type calcium channels are formed by two α-subunits, Cav1.2 (α1C) and Cav1.3 (α1D). In contrast to the uniform expression pattern of Cav1.2, Cav1.3 is highly expressed in sino-atrial node (SAN) and atria...
