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  1. No Access

    Article

    Photoselective sequencing: microscopically guided genomic measurements with subcellular resolution

    In biological systems, spatial organization and function are interconnected. Here we present photoselective sequencing, a new method for genomic and epigenomic profiling within morphologically distinct regions...

    Sarah M. Mangiameli, Haiqi Chen, Andrew S. Earl, Julie A. Dobkin… in Nature Methods (2023)

  2. No Access

    Article

    Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor

    Here we describe TRACE (T7 polymerase-driven continuous editing), a method that enables continuous, targeted mutagenesis in human cells using a cytidine deaminase fused to T7 RNA polymerase. TRACE induces high...

    Haiqi Chen, Sophia Liu, Samuel Padula, Daniel Lesman… in Nature Biotechnology (2020)