5 Result(s)
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Article
Open AccessFinaleMe: Predicting DNA methylation by the fragmentation patterns of plasma cell-free DNA
Analysis of DNA methylation in cell-free DNA reveals clinically relevant biomarkers but requires specialized protocols such as whole-genome bisulfite sequencing. Meanwhile, millions of cell-free DNA samples ar...
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Article
Open AccessAuthor Correction: A framework for clinical cancer subty** from nucleosome profiling of cell-free DNA
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Article
Open AccessA framework for clinical cancer subty** from nucleosome profiling of cell-free DNA
Cell-free DNA (cfDNA) has the potential to inform tumor subtype classification and help guide clinical precision oncology. Here we develop Griffin, a framework for profiling nucleosome protection and accessibi...
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Article
Open AccessScalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling of tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies is uncertain. Here we report ichorCNA,...
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Article
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
BET inhibitors that target bromodomain chromatin readers such as BRD4 are being explored as potential therapeutics in cancer; here triple-negative breast cancer cell lines are shown to respond to BET inhibitor...
