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Article
Open AccessThe survival benefit of adjuvant trastuzumab with or without chemotherapy in the management of small (T1mic, T1a, T1b, T1c), node negative HER2+ breast cancer
There is limited data regarding the added benefit of adjuvant systemic therapy in the management of small, node-negative, HER2+ breast cancer. In a multi-institutional retrospective analysis using the American...
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Article
Open AccessFinaleMe: Predicting DNA methylation by the fragmentation patterns of plasma cell-free DNA
Analysis of DNA methylation in cell-free DNA reveals clinically relevant biomarkers but requires specialized protocols such as whole-genome bisulfite sequencing. Meanwhile, millions of cell-free DNA samples ar...
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Article
Racial Disparities in Breast Cancer: from Detection to Treatment
Update on current racial disparities in the detection and treatment of breast cancer.
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Article
Low Hospital Volume Is Associated with Higher All-Cause Mortality in Black Women with Triple Negative Breast Cancer
This study examines the association between hospital volume and all-cause mortality in Black women with triple negative breast cancer (TNBC) who received surgery and chemotherapy.
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Article
Distress Disorder Histories Relate to Greater Physical Symptoms Among Breast Cancer Patients and Survivors: Findings Across the Cancer Trajectory
Psychological disorders can substantially worsen physical symptoms associated with breast cancer diagnosis and treatment, reducing survivors’ quality of life and increasing recurrence risk. Distress disorders ...
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Open AccessAuthor Correction: A framework for clinical cancer subty** from nucleosome profiling of cell-free DNA
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Open AccessA framework for clinical cancer subty** from nucleosome profiling of cell-free DNA
Cell-free DNA (cfDNA) has the potential to inform tumor subtype classification and help guide clinical precision oncology. Here we develop Griffin, a framework for profiling nucleosome protection and accessibi...
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Article
Open AccessAssociation of body mass index and inflammatory dietary pattern with breast cancer pathologic and genomic immunophenotype in the nurses’ health study
Breast tumor immune infiltration is clearly associated with improved treatment response and outcomes in breast cancer. However, modifiable patient factors associated with breast cancer immune infiltrates are p...
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Article
Massively parallel enrichment of low-frequency alleles enables duplex sequencing at low depth
Assaying for large numbers of low-frequency mutations requires sequencing at extremely high depth and accuracy. Increasing sequencing depth aids the detection of low-frequency mutations yet limits the number o...
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Article
Open AccessMatched cohort study of germline BRCA mutation carriers with triple negative breast cancer in brightness
In the BrighTNess trial, carboplatin added to neoadjuvant chemotherapy (NAC) was associated with increased pathologic complete response (pCR) rates in patients with stage II/III triple-negative breast cancer (...
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Article
Patient preferences and adherence to adjuvant GnRH analogs among premenopausal women with hormone receptor positive breast cancer
Adjuvant ovarian function suppression (OFS) in premenopausal hormone receptor (HR) positive breast cancer (BC) improves survival. Adherence to adjuvant gonadotropin-releasing hormone analogs (GnRHa) remains a ...
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Article
Open AccessCirculating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa
Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as pa...
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Open AccessModeling clonal structure over narrow time frames via circulating tumor DNA in metastatic breast cancer
Circulating tumor DNA (ctDNA) offers minimally invasive means to repeatedly interrogate tumor genomes, providing opportunities to monitor clonal dynamics induced by metastasis and therapeutic selective pressur...
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Article
Open AccessGenomic features of rapid versus late relapse in triple negative breast cancer
Triple-negative breast cancer (TNBC) is a heterogeneous disease and we have previously shown that rapid relapse of TNBC is associated with distinct sociodemographic features. We hypothesized that rapid versus ...
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Article
Open AccessMolecular subty** and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer: the FUTURE trial
Triple-negative breast cancer (TNBC) is a highly heterogeneous disease, and molecular subty** may result in improved diagnostic precision and targeted therapies. Our previous study classified TNBCs into four...
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Open AccessClinical impact of interruption in adjuvant Trastuzumab therapy in patients with operable HER-2 positive breast cancer
Trastuzumab-induced cardiotoxicity (TIC) can lead to early discontinuation of adjuvant therapy, however there is limited evidence on long-term survival outcomes in patients with operable human epidermal growth...
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Article
Efficacy of different dosing schedules of capecitabine for metastatic breast cancer: a single-institution experience
Purpose Capecitabine is widely used as a single agent on a 21-day cycle in the management of metastatic breast cancer (MBC). Our primary objective was to compare the standard dosing of capecitabine (Arm A: days 1...
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Article
Fractional CO2 laser therapy for genitourinary syndrome of menopause for breast cancer survivors
Fractional CO2 laser therapy is an emerging treatment for genitourinary syndrome of menopause (GSM). The objective of this study was to determine the feasibility and preliminary efficacy of fractional CO2 lase...
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Article
Open AccessErythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study
Previous studies of fatty acids and breast cancer risk have shown mixed results, which may be due in part to tumor heterogeneity. Prior research has also illustrated an important role of specific fatty acids i...
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Open AccessMetastatic breast cancer patient perceptions of somatic tumor genomic testing
To assess metastatic breast cancer (MBC) patient psychological factors, perceptions, and comprehension of tumor genomic testing.
