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Article
Open AccessPredicting tumour content of liquid biopsies from cell-free DNA
Liquid biopsy is a minimally-invasive method of sampling bodily fluids, capable of revealing evidence of cancer. The distribution of cell-free DNA (cfDNA) fragment lengths has been shown to differ between heal...
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Article
Open AccessGenome-wide mutational signatures in low-coverage whole genome sequencing of cell-free DNA
Mutational signatures accumulate in somatic cells as an admixture of endogenous and exogenous processes that occur during an individual’s lifetime. Since dividing cells release cell-free DNA (cfDNA) fragments ...
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Article
Open AccessTumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients
Cell-free DNA (cfDNA) profiling is increasingly used to guide cancer care, yet mutations are not always identified. The ability to detect somatic mutations in plasma depends on both assay sensitivity and the f...
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Article
Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid
Diffuse gliomas are the most common malignant brain tumours in adults and include glioblastomas and World Health Organization (WHO) grade II and grade III tumours (sometimes referred to as lower-grade gliomas)...
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Article
Open AccessErratum: The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes
Nature Communications 7 Article number:11479 (2016); Published: 10 May 2016; Updated: 6 June 2016. The original version of this Article contained an error in the spelling of ‘refine’ in the title of the paper....
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Article
Open AccessThe somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes
The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study, we sequence 173 genes in 2,433 primary breast tumou...
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Article
Open AccessMultifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer
Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic heterogeneity is unknown. Here we follow a patient ...
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Article
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
A proof of principle study shows that by exome sequencing of cell-free circulating DNA from cancer patient plasma samples, the genomic evolution of metastatic cancers and the acquisition of resistance in respo...
