16 Result(s)
within
Dan** Huang
Biomedicine
English
Oncology
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Article
Open AccessEndothelial-derived small extracellular vesicles support B-cell acute lymphoblastic leukemia development
The bone marrow niche plays an important role in leukemia development. However, the contributions of different niche components to leukemia development and their underlying mechanisms remain largely unclear.
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Article
Open AccessEfficacy and safety of PD-1/PD-L1 inhibitors combined with anti-angiogenic therapy for the unresectable hepatocellular carcinoma and the benefit for hepatitis B virus etiology subgroup: a systematic review and meta-analysis of randomized controlled trials
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death, worldwide. The predominant causative factor for HCC is hepatitis B virus (HBV) infection. We conducted a meta-analysis to esti...
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Article
Open AccessClassification prediction of pancreatic cystic neoplasms based on radiomics deep learning models
Preoperative prediction of pancreatic cystic neoplasm (PCN) differentiation has significant value for the implementation of personalized diagnosis and treatment plans. This study aimed to build radiomics deep ...
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Open AccessMultiplexed immunofluorescence analysis of CAF-markers, EZH2 and FOXM1 in gastric tissue: associations with clinicopathological parameters and clinical outcomes
The aim of this study is to explore the expression and clinical relevance of CAF-associated markers, EZH2 and FOXM1 in gastric samples.
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Article
Open AccessA study protocol of a randomized phase II trial of perioperative chemoimmunotherapy verses perioperative chemoimmunotherapy plus preoperative chemoradiation for locally advanced gastric (G) or gastroesophageal junction (GEJ) adenocarcinoma: the NeoRacing study
Perioperative chemotherapy (ChT) and preoperative chemoradiation (CRT) are both the standard treatments for locally advanced gastric cancer (LAGC). CRT can achieve a higher pathological complete regression (pC...
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Article
Open AccessHIF1α-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression
Circular RNAs (circRNAs) play an important role in the progression of non-small cell lung cancer (NSCLC), especially under tumor hypoxia. However, the precise functions and underlying mechanisms of dysregulate...
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Open AccessMolecular signatures of tumor progression in pancreatic adenocarcinoma identified by energy metabolism characteristics
In this study, we performed a molecular evaluation of primary pancreatic adenocarcinoma (PAAD) based on the comprehensive analysis of energy metabolism-related gene (EMRG) expression profiles.
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Article
The role of testosterone replacement therapy and statin use, and their combination, in prostate cancer
Previous studies have reported conflicting results in the associations of testosterone replacement therapy (TTh) and statins use with prostate cancer (PCa). However, the combination of these treatments with PC...
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Article
Open AccessCorrection: CSN6–TRIM21 axis instigates cancer stemness during tumorigenesis
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessCSN6–TRIM21 axis instigates cancer stemness during tumorigenesis
Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and recurrence. However, the mechanism of CSC formation, maintenance and expansion in colorectal cancer (CRC) remains poorly character...
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Article
Open AccessLong-course neoadjuvant chemoradiotherapy with versus without a concomitant boost in locally advanced rectal cancer: a randomized, multicenter, phase II trial (FDRT-002)
This study was designed to explore whether an intensified chemoradiotherapy (CRT) led to a better clinical outcome in locally advanced rectal cancer.
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Article
Open AccessStudy protocol of a randomized phase III trial of comparing preoperative chemoradiation with preoperative chemotherapy in patients with locally advanced gastric cancer or esophagogastric junction adenocarcinoma: PREACT
The prognosis of patients with locally advanced gastric cancer or esophagogastric junction adenocarcinoma is still dismal. There are no standard treatment strategies for these patients. Multidisciplinary team ...
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Article
The macroscopic and microscopic effect of low-frequency whole-body vibration after cerebral ischemia in rats
Whole body vibration (WBV) has been applied in stroke patients with uncertain effects on motor and sensory dysfunction, and its effects on neurogenesis have not been studied yet. Here, we intended to explore t...
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Article
Non-invasive remote ischemic postconditioning stimulates neurogenesis during the recovery phase after cerebral ischemia
Ischemic postconditioning (IPostC) has been reported to have neuroprotection against ischemic diseases, and one cycle of IPostC induces neurogenesis when treated nearby. To expanding these effects, we explored...
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Article
Bif-1 promotes tumor cell migration and metastasis via Cdc42 expression and activity
Tumor metastasis is the process by which tumor cells disseminate from tumors and enter nearby and distant microenvironments for new colonization. Bif-1 (BAX-interacting factor 1), which has a BAR domain and an...
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Article
Open AccessThe Philadelphia chromosome in leukemogenesis
The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML). In leukemia cells, ...
