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  1. Article

    Open Access

    ISSLS PRIZE in Basic Science 2024: superiority of nucleus pulposus cell- versus mesenchymal stromal cell-derived extracellular vesicles in attenuating disc degeneration and alleviating pain

    To investigate the therapeutic potential of extracellular vesicles (EVs) derived from human nucleus pulposus cells (NPCs), with a specific emphasis on Tie2-enhanced NPCs, compared to EVs derived from human bon...

    Luca Ambrosio, Jordy Schol, Clara Ruiz-Fernandez, Shota Tamagawa… in European Spine Journal (2024)

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  2. No Access

    Article

    Prognostic impact of respiratory dysfunction in elderly patients with cervical spinal cord injury and/or fractures: a multicenter survey

    To investigate the impact of early post-injury respiratory dysfunction for neurological and ambulatory ability recovery in patients with cervical spinal cord injury (SCI) and/or fractures.

    Ryosuke Hirota, Yoshinori Terashima, Hirofumi Ohnishi… in European Spine Journal (2023)

  3. No Access

    Article

    The factors related to the poor ADL in the patients with osteoporotic vertebral fracture after instrumentation surgery

    Osteoporotic vertebral fracture (OVF) with nonunion or neurological deficit may be a candidate for surgical treatment. However, some patients do not show improvement as expected. Therefore, we conducted a nati...

    Kazuma Murata, Yuji Matsuoka, Hirosuke Nishimura, Kenji Endo… in European Spine Journal (2020)

  4. No Access

    Article

    Sagittal alignment of the cervical spine in adolescent idiopathic scoliosis: a comparative study of 42 adolescents with idiopathic scoliosis and 24 normal adolescents

    Kyphosis of the cervical spine has been reported in patients with adolescent idiopathic scoliosis (AIS). However, few reports have compared sagittal spine alignment of AIS patients with that of the normal popu...

    Akihiko Hiyama, Daisuke Sakai, Masahiko Watanabe, Hiroyuki Katoh… in European Spine Journal (2016)

  5. No Access

    Article

    Effect of depression and neuropathic pain using questionnaires on quality of life in patients with low back pain; cross-sectional retrospective study

    The present study investigated the percentage of low back pain (LBP) patients who have depressive symptoms and neuropathic pain and analyzed the effects of these on the quality of life (QOL) in these patients.

    Akihiko Hiyama, Masahiko Watanabe, Hiroyuki Katoh, Masato Sato… in European Spine Journal (2016)

  6. No Access

    Article

    Evaluation of quality of life and neuropathic pain in patients with low back pain using the Japanese Orthopedic Association Back Pain Evaluation Questionnaire

    To examine the impact that neuropathic or nociceptive pain has on the quality of life (QOL) in patients with low back pain (LBP) using the Japanese Orthopedic Association Back Pain Evaluation Questionnaire (J...

    Akihiko Hiyama, Masahiko Watanabe, Hiroyuki Katoh, Masato Sato… in European Spine Journal (2015)

  7. No Access

    Article

    Future perspectives of cell-based therapy for intervertebral disc disease

    Intervertebral disc degeneration is a primary cause of low back pain and has a high societal cost. Research on cell-based therapies for intervertebral disc disease is emerging, along with the interest in biolo...

    Daisuke Sakai in European Spine Journal (2008)

  8. No Access

    Article

    A phenotypic comparison of intervertebral disc and articular cartilage cells in the rat

    The basic molecular characteristics of intervertebral disc cells are still poorly defined. This study compared the phenotypes of nucleus pulposus (NP), annulus fibrosus (AF) and articular cartilage (AC) cells ...

    Cynthia R. Lee, Daisuke Sakai, Tomoko Nakai, Kanae Toyama… in European Spine Journal (2007)