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Article
Prognostic impact of a reduction in the fibrosis-4 index among patients hospitalized with acute heart failure
Although the fibrosis-4 index (FIB-4) is associated with right atrial pressure or prognosis in acute heart failure (AHF), the prognostic impact of its reduction during hospitalization remains uncertain. We inc...
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Article
Clinical and prognostic implications of hyaluronic acid in hospitalized patients with heart failure
We investigated the clinical and prognostic implications of hyaluronic acid, a liver fibrosis marker, in patients with heart failure. We measured hyaluronic acid levels on admission in 655 hospitalized patient...
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Article
Open AccessThe potential clinical utility of cell-free DNA for gastric cancer patients treated with nivolumab monotherapy
To assess the potential clinical utility of cell-free DNA (cfDNA)-based biomarkers for identifying gastric cancer (GC) patients who benefit from nivolumab. From 31 GC patients treated with nivolumab monotherap...
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Article
Blood pressure in heart failure management and prevention
Hypertension is a leading cause of heart failure and other cardiovascular diseases. Its role in the pathogenesis of heart failure with reduced ejection fraction (HFrEF) differs from that in heart failure with ...
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Article
Open AccessMacrophage numbers in the marginal area of sarcomas predict clinical prognosis
Even when treated comprehensively by surgery, chemotherapy, and radiotherapy, soft-tissue sarcoma has an unfavorable outcome. Because soft-tissue sarcoma is rare, it is the subject of fewer clinicopathological...
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Article
Open AccessProposal of a novel pipeline involving precise bronchoscopy of distal peripheral pulmonary lesions for genetic testing
Next-generation sequencing (NGS) has become increasingly more important for lung cancer management. We now expect biopsies to be sensitive, safe, and yielding sufficient samples for NGS. In this study, we prop...
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Article
Open AccessAssociation between class of foundational medication for heart failure and prognosis in heart failure with reduced/mildly reduced ejection fraction
We clarified the association between changes in the number of foundational medications for heart failure (FMHF) during hospitalization for worsening heart failure (HF) and post-discharge prognosis. We retrospe...
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Article
Open AccessSarcopenic obesity is associated with impaired physical function and mortality in older patients with heart failure: insight from FRAGILE-HF
The purpose of this study was to clarify the prevalence, association with frailty and exercise capacity, and prognostic implication of sarcopenic obesity in patients with heart failure.
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Article
Open AccessPrognostic value of postural hypotension in hospitalized patients with heart failure
Although postural hypotension (PH) is reportedly associated with mortality in the general population, the prognostic value for heart failure is unclear. This was a post-hoc analysis of FRAGILE-HF, a prospectiv...
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Article
Open AccessClinical implication of initial intravenous diuretic dose for acute decompensated heart failure
Although intravenous diuretics is a cornerstone of acute heart failure treatment (AHF), its optimal initial dose is unclear. This is a post-hoc analysis of the REALITY-AHF, a prospective multicentre observational...
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Article
Open AccessAspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure
Frailty is a common comorbidity associated with adverse events in patients with heart failure, and early recognition is key to improving its management. We hypothesized that the AST to ALT ratio (AAR) could be...
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Article
Open AccessDisorganization of intercalated discs in dilated cardiomyopathy
Dilated cardiomyopathy (DCM) is a primary myocardial disease, the pathology of which is left ventricular or biventricular dilation and impaired myocardial contractility. The clinical and pathological diagnosis...
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Article
Correction to: Multidomain Frailty in Heart Failure: Current Status and Future Perspectives
A correction to this paper has been published: https://doi.org/10.1007/s11897-021-00516-z
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Article
Multidomain Frailty in Heart Failure: Current Status and Future Perspectives
With a worldwide aging population, frailty and heart failure (HF) have become issues that need to be addressed urgently in cardiovascular clinical practice. In this review, we outline the clinical implications...
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Article
Open AccessCollision of Epstein–Barr virus-positive and -negative gastric cancer, diagnosed by molecular analysis: a case report
Epstein–Barr virus (EBV)-positive gastric carcinoma (GC) is defined by the proliferation of GC cells with EBV infection. The co-existence of EBV-positive and -negative components in a single GC is rare. We rep...
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Article
Prognostic impact of a novel index of nutrition and inflammation for patients with acute decompensated heart failure
Malnutrition and systemic inflammation are associated with poor outcomes in patients with heart failure. Recent studies have reported that the advanced lung cancer inflammation index (ALI), derived from the bo...
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Article
Open AccessDifferential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia
Human papillomavirus (HPV) infection is a primary cause of cervical cancer. Although epidemiologic study revealed that carcinogenic risk differs according to HPV genotypes, the expression patterns of HPV-deriv...
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Article
Fibrosis-4 index reflects right-sided filling pressure in patients with heart failure
The fibrosis-4 index (FIB-4 index) is a marker of liver fibrosis. It has been reported that the FIB-4 index in compensated phase is associated with estimated right-sided filling pressure and poor prognosis in ...
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Article
Open AccessPost-mortem Plasma Cell-Free DNA Sequencing: Proof-of-Concept Study for the “Liquid Autopsy”
Recent genomic studies on cancer tissues obtained during rapid autopsy have provided insights into the clonal evolution and heterogeneity of cancer. However, post-mortem blood has not been subjected to genetic...
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Article
Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment
Tumor-derived extracellular vesicles (TEVs) secreted into the blood create a pre-metastatic niche in distant organs; however, it is unclear how TEVs are delivered and how they affect stromal cells in the tumor...
