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Open AccessA feedback loop of PPP and PI3K/AKT signal pathway drives regorafenib-resistance in HCC
Hepatocellular carcinoma (HCC) is a principal type of liver cancer with high incidence and mortality rates. Regorafenib is a novel oral multikinase inhibitor for second-line therapy for advanced HCC. However, ...
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Open AccessPathological characteristics and immune microenvironment of SMARCA4-deficient undifferentiated uterine sarcoma
SMARCA4-deficient undifferentiated uterine sarcoma (SDUS) is a highly invasive single-gene malignant tumor caused by mutations in the SMARCA4 gene. SDUS has a poor prognosis, with no established treatment strateg...
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Open AccessTemporal inhibition of chromatin loo** and enhancer accessibility during neuronal remodeling
During development, loo** of an enhancer to a promoter is frequently observed in conjunction with temporal and tissue-specific transcriptional activation. The chromatin insulator-associated protein Alan Shep...
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Open AccessHoley two-dimensional transition metal oxide nanosheets for efficient energy storage
Transition metal oxide nanomaterials are promising electrodes for alkali-ion batteries owing to their distinct reaction mechanism, abundant active sites and shortened ion diffusion distance. However, detailed ...
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Open AccessFunctioning styles of personality disorders and five-factor normal personality traits: a correlation study in Chinese students
Previous studies show that both the categorical and dimensional descriptors of personality disorders are correlated with normal personality traits. Recently, a 92-item inventory, the Parker Personality Measure...
