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  1. Article

    Open Access

    Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor

    The zinc-dependent metalloprotease meprin α is predominantly expressed in the brush border membrane of proximal tubules in the kidney and enterocytes in the small intestine and colon. In normal tissue homeosta...

    Charles Bayly-Jones, Christopher J. Lupton, Claudia Fritz… in Nature Communications (2022)

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  2. No Access

    Protocol

    Heterologous Expression of the Astacin Protease Meprin β in Pichia pastoris

    Meprins are zinc-dependent proteases of the metzincin superfamily of metalloproteases. The enzymes are extracellular multi-domain proteins which are stabilized by disulfide bridges, dimerization, and glycosyla...

    Dagmar Schlenzig, Stephan Schilling in Matrix Metalloproteases (2017)

  3. No Access

    Article

    Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

    Some Aβ peptides contain pyroglutamate modifications that affect the aggregation properties of these peptides. The authors find that the enzyme glutaminyl cyclase is responsible for this pyroglutamate modifica...

    Stephan Schilling, Ulrike Zeitschel, Torsten Hoffmann, Ulrich Heiser… in Nature Medicine (2008)

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    Chapter

    Acylated Hydroxamates as Selective and Highly Potent Inhibitors of Dipeptidyl Peptidase I

    The compounds 10–14 which are N-dipeptidyl derivatives of O-acyl hydroxamates proved to be potent, selective and irreversible inhibitors of DP I.

    André J. Niestroj, Dagmar Schlenzig… in Dipeptidyl Aminopeptidases in Health and D… (2003)