186,587 Result(s)
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Article
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Energy metabolism has always been a hot topic in cancer progression and targeted therapy, and exploring the role of genes in energy metabolic pathways in cancer cells has become key to address this issue. Euka...
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Development of a highly selective and sensitive fluorescent chemosensory for zinc ion detection in aqueous ethanol solution: synthesis of a new aza-oxo macrocycle using high-dilution condition method
Utilizing a high-dilution condition method, a new aza-oxo macrocycle, referred to as L, was synthesized as a chemosensor. The chemosensing capabilities of L were thoroughly investigated using fluorescence stud...
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Open AccessEmploying supramolecular chemistry strategies for the separation of mixtures of anisole and bromoanisole isomers
In the present work, host compounds trans-9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboxylate (H1), trans-α,α,α’,α’-tetraphenyl-9,10-dihydro-9,10-ethanoanthracene-11,12-dimethanol (H2) and trans-α,α,α’,α’-tetr...
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Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cancer cell biology
Lysophosphatidic acid (LPA) is a simple lipid which is endogenously synthesized from lysophosphatidylcholine (LPC) by autotaxin (ATX). LPA mediates a variety of cellular responses through the binding of G prot...
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Synthesis and characterization of new rotaxanes from related crown compounds
Physical manipulation can be carried out on molecules and cells through the utilization of nanomachines which are machines with nano dimensions. There are different types of nanomachines. Among them, rotaxanes...
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Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway
Vesicle-associated membrane protein 8 (VAMP8), a soluble n-ethylmaleimide-sensitive factor receptor protein, acts as an oncogenic gene in the progression of several malignancies. Nevertheless, the roles and me...
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Modelling spatio-temporal interactions between second messengers Ca \(^{2+}\) and cAMP in a pancreatic \(\beta \) -cell
Calcium serves as a widespread second messenger in almost every human and animal cell. The regulation of various cellular processes, such as transcriptional control and the kinetics of membrane channels, is si...
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Electrocontractile remodeling of isolated cardiomyocytes induced during early-stage hypercholesterolemia
Hypercholesterolemia is one of the most important risk factors for cardiovascular diseases. However, it is mostly associated with vascular dysfunction and atherosclerotic lesions, while evidence of direct effe...
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Kinetics and thermodynamics of β-cyclodextrin-NH2/β-carotene complexation: how much energy is required to include a hydrophobic group in the macrocycle cavity?
To improve the efficiency of cyclodextrins as carotenoid carriers, the kinetics and thermodynamics of the inclusion complex formation between modified β-cyclodextrin (βCD-NH2) and β-carotene (βCT) were studied us...
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Article
Open AccessRational design of metal-responsive functional DNA supramolecules
DNA molecules have excellent molecular recognition abilities through the complementary hydrogen-bonded base pairing. Since the hybridization of oligonucleotides can be programmed based on the sequences of the ...
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METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis
Numerous studies have indicated that N6-methyladenosine (m6A) and lncRNAs play pivotal roles in human cancer. However, the underlying functions and mechanisms of m6A-lncRNA in the physiological processes of breas...
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Open AccessMir22hg facilitates ferritinophagy-mediated ferroptosis in sepsis by recruiting the m6A reader YTHDC1 and enhancing Angptl4 mRNA stability
Ferritinophagy-mediated ferroptosis plays a crucial role in fighting pathogen aggression. The long non-coding RNA Mir22hg is involved in the regulation of ferroptosis and aberrantly overexpression in lipopolys...
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Probing the interaction of ciprofol and human serum albumin using multiple spectroscopies
The interaction between ciprofol and human serum albumin (HSA) was studied using spectroscopy-based approaches at different temperatures under simulated physiological conditions in vitro. Quenching of intrinsic T...
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Formulation and evaluation of multicomponent inclusion complex of cyclosporine A
Cyclosporine A (CP) inclusion complex using cyclodextrin (binary) and cyclodextrin with TPGS (ternary) was prepared by the freeze-drying method. The phase solubility study was performed to calculate the solubi...
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Retraction Note: Macroscopic supramolecular self-assembly detection based on HALCON machine vision
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Open AccessThe impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson’s disease model using SH-SY5Y cells depends on their differentiation state
Inward rectifying potassium channels sensitive to ATP levels (KATP) have been the subject of investigation for several decades. Modulators of KATP channels are well-established treatments for metabolic as well...
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Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis
Septic cardiomyopathy is a severe cardiovascular disease with a poor prognosis. Previous studies have reported the involvement of ferroptosis in the pathogenesis of septic cardiomyopathy. SGLT2 inhibitors such...
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Open AccessInvestigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells
Miltefosine (MLT) is a broad-spectrum drug included in the alkylphospholipids (APL) used against leishmania and various types of cancer. The most crucial feature of APLs is that they are thought to only kill c...
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Balanced Polysulfide Containment and Lithium Ion Transport in Lithium-Sulfur Batteries via Nitrogen-doped Carbon Hollow Multi-shelled Structures on Modified Separators
Representing the next-generation technology in lithium-ion batteries, lithium-sulfur (Li-S) batteries offer increased specific energy without relying on scarce metals like nickel and cobalt, but suffer from a ...
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MOF-derived 1D CGO Cathode for Efficient Solid Oxide Electrolysis Cells
Solid oxide electrolysis cells (SOECs) provide a promising way for converting renewable energy into chemical fuels. Traditionally, NiO/CGO (nickel-gadolinium doped ceria) cermet has shown its excellent propert...
