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  1. Article

    Open Access

    Knockout of NMDA-receptors from parvalbumin interneurons sensitizes to schizophrenia-related deficits induced by MK-801

    It has been suggested that a functional deficit in NMDA-receptors (NMDARs) on parvalbumin (PV)-positive interneurons (PV-NMDARs) is central to the pathophysiology of schizophrenia. Supportive evidence come fro...

    A M Bygrave, S Masiulis, E Nicholson, M Berkemann, C Barkus… in Translational Psychiatry (2016)

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  2. Article

    Open Access

    What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit

    The GRIA1 locus, encoding the GluA1 (also known as GluRA or GluR1) AMPA glutamate receptor subunit, shows genome-wide association to schizophrenia. As well as extending the evidence that glutamatergic abnormaliti...

    C Barkus, D J Sanderson, J N P Rawlins, M E Walton, P J Harrison… in Molecular Psychiatry (2014)

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  3. Article

    The contribution of distinct subregions of the ventromedial frontal cortex to emotion, social behavior, and decision making

    Damage to the ventromedial frontal cortex (VMFC) in humans is associated with deficits in decision making. Decision making, however, often happens while people are interacting with others, where it is importan...

    P. H. Rudebeck, D. M. Bannerman… in Cognitive, Affective, & Behavioral Neurosc… (2008)

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  4. No Access

    Article

    Mice overexpressing the 5-hydroxytryptamine transporter show no alterations in feeding behaviour and increased non-feeding responses to fenfluramine

    The 5-HT transporter (5-HTT) is implicated in the regulation of appetite. Expression of the 5-HTT varies in the human population, and this variation may determine both individual differences in feeding and abn...

    A. Pringle, K. A. Jennings, S. Line, D. M. Bannerman, S. Higgs… in Psychopharmacology (2008)

  5. No Access

    Article

    The drugs don’t work—or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory

    The aim of this article is to provide a review of studies using N-methyl-d-aspartate (NMDA) receptor antagonists to assess the hippocampal long-term potentiation (LTP)/learning hypothesis.

    D. M. Bannerman, J. N. P. Rawlins, M. A. Good in Psychopharmacology (2006)

  6. No Access

    Article

    Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort

    Although tasks assessing the role of dopamine in effort-reward decisions are similar to those concerned with the role of serotonin in impulsive choice in that both require analysis of the costs and benefits of...

    F. Denk, M. E. Walton, K. A. Jennings, T. Sharp, M. F. S. Rushworth… in Psychopharmacology (2005)

  7. No Access

    Article

    Restoration of spatial working memory by genetic rescue of GluR-A–deficient mice

    Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3–CA1 long-term potentiation (LTP) and have profoundly impaired hippocampu...

    W B Schmitt, R Sprengel, V Mack, R W Draft, P H Seeburg… in Nature Neuroscience (2005)

  8. No Access

    Article

    Spatial memory dissociations in mice lacking GluR1

    Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3–CA1 long-term potentiation. We now report that they showed normal spatial reference learning and memory, bot...

    D. Reisel, D. M. Bannerman, W. B. Schmitt, R. M. J. Deacon, J. Flint… in Nature Neuroscience (2002)

  9. No Access

    Article

    Cytotoxic lesions of the hippocampus increase social investigation but do not impair social-recognition memory

    A number of studies have implicated the hippocampal formation in social-recognition memory in the rat. The present study addressed this issue directly by assessing the effects of cytotoxic lesions confined to...

    D.M. Bannerman, M. Lemaire, S. Beggs, J.N.P. Rawlins… in Experimental Brain Research (2001)

  10. No Access

    Article

    Distinct components of spatial learning revealed by prior training and NMDA receptor blockade

    SYNAPTIC plasticity dependent on N-methyl-D-aspartate (NMDA) receptors is thought to underlie certain types of learning and memory1–3. In support of this, both hippocampal long-term potentiation and spatial learn...

    D. M. Bannerman, M. A. Good, S. P. Butcher, M. Ramsay, R. G. M. Morris in Nature (1995)