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  1. Article

    Open Access

    p15 INK4b in bladder carcinomas: decreased expression in superficial tumours

    The p15 gene which encodes a cyclin-dependent kinase inhibitor, is located in the 9p21 chromosomal region that is frequently deleted in human bladder transitional cell carcinomas (TCCs). The aim of the present pa...

    M A Le Frère-Belda, D Cappellen, A Daher, S Gil-Diez-de-Medina… in British Journal of Cancer (2001)

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  2. Article

    Open Access

    Low E-cadherin expression in bladder cancer at the transcriptional and protein level provides prognostic information

    We studied E-cadherin down-regulation at the protein level in frozen sections of 111 bladder tumours and 13 normal bladder specimens by means of immunohistochemistry, and at the mRNA level by semi-quantitative...

    Z Popov, S Gil-Diez de Medina, M-A Lefrere-Belda, A Hoznek… in British Journal of Cancer (2000)

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  3. No Access

    Article

    Immune response following intravesical bacillus Calmette-Guerin instillations in superficial bladder cancer: a review

    Local immunotherapy with bacillus Calmette-Guerin (BCG) can prevent recurrences and progression of superficial bladder cancer, but the antitumoral mechanism of BCG is still unclear. The first event seems to b...

    J. J. Patard, F. Saint, F. Velotti, C. C. Abbou, D. K. Chopin in Urological Research (1998)

  4. No Access

    Article

    Prognostic factors in superficial bladder cancer

    A large body of evidence suggests that intravescial prophylaxis using vacilus Calmette-Guérin can favorably alter the natural history of superficial bladder cancer. The search for prognostic factors impacting ...

    D. K. Chopin, Z. Popov, V. Ravery, J. Bellot, A. Hoznek… in World Journal of Urology (1993)

  5. No Access

    Article

    Mechanisms of action of bacillus Calmette-Guérin in the treatment of superficial bladder cancer

    Local immunotherapy with bacillus Calmette-Guérin (BCG) is an effective treatment to prevent recurrence and progression of superficial bladder cancer, but the antitumor mechanism of action of BCG remains uncle...

    J. J. Patard, D. K. Chopin, L. Boccon-Gibod in World Journal of Urology (1993)

  6. No Access

    Article

    Immunohistochemical detection of acidic fibroblast growth factor in bladder transitional cell carcinoma

    Acidic fibroblast growth factor (aFGF) is a regulatory peptide which, on account of its structural homologies with the products of oncogenes, is involved in cell proliferation, differentiation, and motility. W...

    V. Ravery, J. Jouanneau, S. Gil Diez, C. C. Abbou, J. P. Caruelle… in Urological Research (1992)

  7. No Access

    Article

    Monoclonal antibodies in bladder cancer cytology

    Conventional urinary cytology is the only routine noninvasive test accepted for the early detection and follow-up of bladder cancer. However, accuracy is achieved only in high-grade tumors and the method requi...

    D. K. Chopin, J.-C. Laurent in World Journal of Urology (1991)

  8. No Access

    Article

    Immunopathology of urothelial lesions: immunological markers as predictive for clinical aggressiveness

    Treatment of superficial bladder cancer is shifting toward a more conservative attitude with a widespread use of intravesical immunotherapy. There is a need for markers which can reliably identified patients a...

    D. K. Chopin, K. E. Whitmore, C. C. Abbou, J. B. DeKernion in World Journal of Urology (1987)

  9. No Access

    Article

    Detection of transitional cell carcinoma in bladder by intravesical injection of Monoclonal antibodies

    Monoclonal antibodies produced against tumor associated antigens of human bladder transitional cell carcinoma have proved to be useful in detecting malignant cells in tumor sections and bladder washings. The p...

    D. K. Chopin, J. B. deKernion in Urological Research (1986)