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  1. No Access

    Article

    Repopulation of B-lymphocytes with restricted gene expression using haematopoietic stem cells engineered with lentiviral vectors

    B-lymphocytes play a key role in the pathogenesis of many immune-mediated diseases, such as autoimmune and atopic diseases. Therefore, targeting B-lymphocytes provides a rationale for refining strategies to tr...

    T E Taher, C Tulone, R Fatah, F D'Acquisto, D J Gould, R A Mageed in Gene Therapy (2008)

  2. No Access

    Article

    Vectors for the treatment of autoimmune disease

    Gene therapy has been applied in a variety of experimental models of autoimmunity with some success. In this article, we outline recent developments in gene therapy vectors, discuss advantages and disadvantage...

    D J Gould, P Favorov in Gene Therapy (2003)

  3. No Access

    Article

    A novel doxycycline inducible autoregulatory plasmid which displays ‘on’/‘off’ regulation suited to gene therapy applications

    The development of transcriptionally controlled systems which function in eukaryotic cells are important for achieving regulated gene expression in gene therapy. In this study we combined the components of the...

    D J Gould, M Berenstein, H Dreja, F Ledda, O L Podhajcer, Y Chernajovsky in Gene Therapy (2000)

  4. No Access

    Article

    Inflammatory mediators and cellular infiltration of the lungs in a guinea pig model of the late asthmatic reaction

    Alterations in cell numbers, vascular permeability, and concentrations of various inflammatory mediators in the lung were measured in a guinea pig model of the late asthmatic reaction. Animals sensitized by in...

    A. F. Walls, Y. K. Rhee, D. J. Gould, C. Walters, C. Robinson, M. K. Church… in Lung (1991)