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Article
A propensity score–weighted study comparing a two- versus four-weekly pegylated liposomal doxorubicin regimen in metastatic breast cancer
A 4-weekly schedule of pegylated liposomal doxorubicin (PLD) has been approved for the treatment of metastatic breast cancer (MBC). Phase II trials have suggested interest in a 2-weekly regimen. This study aim...
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Article
The genetics of breast cancer susceptibility — Polymorphism and the prospect of their use in a clinical setting
Susceptibility is defined as “the quality or state of being open to, subject to or non-resistant to stimuli, influences and agents”. The concept of genetic susceptibility simply implies that our genes predispo...
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Article
Open AccessPrognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype
Dicer, a ribonuclease, is the key enzyme required for the biogenesis of microRNAs and small interfering RNAs and is essential for both mammalian development and cell differentiation. Recent evidence indicates ...
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Article
Open AccessPolymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer
Inflammation plays a key role in the development of colorectal cancers. We have investigated the relationship between PTGS2 (COX2) polymorphisms and colorectal cancer risk in a hospital based case–control study. ...
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Article
Effects of Colchicine and Colchemid on Synthesis of Deoxyribonucleic Acid in the Skin of the Guinea Pig's Ear in vitro
COLCHICINE and colchemid have been used extensively in vivo and in vitro as a means of halting cells at metaphase in order to make the counting of mitotic figures easier. It is generally assumed that both have a ...
