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Article
Open AccessAntibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients
Anti-PM/Scl antibodies are present in sera from patients with polymyositis (PM), systemic sclerosis (SSc), and PM/SSc overlap syndromes. The prevalence of antibodies against the 75- and 100-kDa PM/Scl proteins...
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Article
Open AccessDiagnostic value of anti-topoisomerase I antibodies in a large monocentric cohort
In the present study, the detection of anti-topoisomerase I (anti-topo I) autoantibodies was evaluated for diagnosis and risk assessment of systemic sclerosis (SSc) patients in a well characterized large monoc...
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Article
Die Rationale für Knochenmarkuntersuchungen bei Patienten mit entzündlich-rheumatischen Erkrankungen
OBJECTIVE: Inflammatory rheumatic diseases and the applied immunosuppressive treatments can lead to bone marrow depressions and promote hematologic malignancies. Our objective was to explore indications for an...
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Article
Prospektive Versorgungsforschungsstudie zur Therapie mit Immunglobulinen (SIGNS)
Nichtmodifizierte humane Immunglobuline (IgG) sind der Standard für die Substitutionstherapie von Patienten mit primären (angeborenen) Immundefekten (PID) sowie sekundären Immundefekten (SID) aufgrund von mult...
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Article
Effect of biofeedback and deep oscillation on Raynaud’s phenomenon secondary to systemic sclerosis: results of a controlled prospective randomized clinical trial
Our aim was to evaluate the effect of deep oscillation and biofeedback on Raynaud’s phenomenon (RP) secondary to systemic sclerosis (SSc). A prospective randomized study was performed in SSc patients receiving...
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Article
Immunoglobulins for primary or secondary immunodeficiency or for immunomodulation in neurological autoimmune diseases: insights from the prospective SIGNS registry
Outside the context of clinical trials, there is a lack of data on the management and long-term outcomes of patients with primary or secondary antibody deficiency (PID and SID), or those with neurological auto...
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Article
Treatment of Neurological Autoimmune Diseases with Immunoglobulins: First Insights from the Prospective SIGNS Registry
Several immunoglobulin (IG) preparations have been approved for the immunomodulatory treatment of the neurological autoimmune diseases (AID) Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating po...
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Article
Open AccessAcute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling
The role of endogenous glucocorticoids (GC) in the initiation and maintenance of rheumatoid arthritis (RA) remains unclear. We demonstrated previously that disruption of GC signalling in osteoblasts results in...
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Article
Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters
Exercise at regular intervals is assumed to have a positive effect on immune functions. Conversely, after spaceflight and under simulated weightlessness (e.g., bed rest), immune functions can be suppressed. We...
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Article
Open AccessBody mass index distribution in rheumatoid arthritis: a collaborative analysis from three large German rheumatoid arthritis databases
METARTHROS (Metabolic impact on joint and bone disease) is a nationwide German network to investigate the overlap between inflammatory and metabolic diseases. The objective of this study was to compare the bod...
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Article
Open AccessSystemic sclerosis associated interstitial lung disease - individualized immunosuppressive therapy and course of lung function: results of the EUSTAR group
Interstitial lung disease in systemic sclerosis (SSc-ILD) is a major cause of SSc-related death. Imunosuppressive treatment (IS) is used in patients with SSc for various organ manifestations mainly to ameliora...
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Article
Long-term glucocorticoid treatment in patients with polymyalgia rheumatica, giant cell arteritis, or both diseases: results from a national rheumatology database
The objective of this study was to evaluate glucocorticoid (GC) use in patients with polymyalgia rheumatica (PMR), giant cell arteritis (GCA) or both diseases (PMR + GCA) under rheumatological care. Data from ...
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Article
The 6MWT as a prognostic tool in pulmonary arterial hypertension: results from the COMPERA registry
In patients with pulmonary arterial hypertension, the 6-Minute Walk Test (6MWT) is recommended for risk stratification and follow-up by all guidelines. However, the prognostic value of the 6MWT has been discus...
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Article
Open AccessSelf-reported medication in community-dwelling older adults in Germany: results from the Berlin Initiative Study
Older adults have the highest drug utilization due to multimorbidity. Although the number of people over age 70 is expected to double within the next decades, population-based data on their medication patterns...
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Article
Open AccessTrends in idiopathic inflammatory myopathies: cross-sectional data from the German National Database
To describe trends in outcomes among patients with idiopathic inflammatory myopathies (IIM) over two decades.
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Article
Open AccessMobile App-based documentation of patient-reported outcomes — 3-months results from a proof-of-concept study on modern rheumatology patient management
Mobile medical applications (Apps) offer innovative solutions for patients’ self-monitoring and new patient management opportunities. Prior to routine clinical application feasibility and acceptance of disease...
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Article
Open AccessDevelopment of a prediction model for mortality and cardiovascular outcomes in older adults taking into account AZGP1
Zinc-alpha 2-glycoprotein (AZGP1) is a serum protein with postulated functions in metabolism, cancer and cardiovascular disease. We developed new prediction models for mortality or cardiovascular events invest...
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Article
Open AccessGender differences in frailty transition and its prediction in community-dwelling old adults
Frailty is very common in old age and often associated with adverse events. Transitioning between frailty states is possible in both directions (improvement and worsening) offering targets for interventions. F...
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Article
Open AccessFacilitated Subcutaneous Immunoglobulin Treatment in Patients with Immunodeficiencies: the FIGARO Study
The FIGARO study aims to provide insights on real-world utilization and tolerability of facilitated subcutaneous immunoglobulin (fSCIG) for primary immunodeficiency disease (PID) or secondary immunodeficiency ...
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Article
Open AccessTransgenic disruption of endogenous glucocorticoid signaling in osteoblasts does not alter long-term K/BxN serum transfer-induced arthritis
Disruption of glucocorticoid (GC) signaling in osteoblasts results in a marked attenuation of acute antibody-induced arthritis. The role of endogenous GCs in chronic inflammatory arthritis is however not fully...
