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  1. No Access

    Article

    Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression

    Cognitive impairment is a frequent manifestation of neuropsychiatric systemic lupus erythematosus, present in up to 80% of patients and leading to a diminished quality of life. In the present study, we used a ...

    Kaitlin R. Carroll, Mark Mizrachi, Sean Simmons, Bahtiyar Toz… in Nature Immunology (2024)

  2. Article

    Open Access

    Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory

    Patients with Systemic lupus erythematosus (SLE) experience various peripheral and central nervous system manifestations including spatial memory impairment. A subset of autoantibodies (DNRAbs) cross-react wit...

    Kelvin Chan, Jacquelyn Nestor, Tomás S. Huerta, Noele Certain… in Nature Communications (2020)

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  3. No Access

    Article

    Maternal antibodies and develo** blood–brain barrier

    We briefly review the protective role of maternal antibodies during fetal development and at early postnatal stages. We describe antibody delivery to fetuses, particularly in the context of the develo** bloo...

    Czeslawa Kowal, Andrew Athanassiou, Huiyi Chen, Betty Diamond in Immunologic Research (2015)

  4. No Access

    Protocol

    Aspects of CNS Lupus: Mouse Models of Anti-NMDA Receptor Antibody Mediated Reactivity

    This chapter describes methods utilized in establishing a mouse model of neuropsychiatric lupus encompassing both cognitive and emotional dysfunction, and a model of the influence of maternal antibody on the d...

    Czeslawa Kowal, Betty Diamond in Autoimmunity (2012)

  5. No Access

    Article

    Losing your nerves? Maybe it's the antibodies

    In this Opinion article, Betty Diamond and colleagues propose that common serum antibodies that crossreact with brain antigens might be responsible for many acquired changes or congenital impairments in cognit...

    Betty Diamond, Patricio T. Huerta, Paola Mina-Osorio… in Nature Reviews Immunology (2009)

  6. No Access

    Article

    Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus

    Children born to mothers with lupus have a higher rate of learning disorders. Now, in mouse studies, Betty Diamond and her colleagues show that neurotoxic antibodies found in mothers with lupus are transferred...

    Ji Y Lee, Patricio T Huerta, Jie Zhang, Czeslawa Kowal, Eva Bertini… in Nature Medicine (2009)

  7. No Access

    Article

    An EαEβ heterodimer dramatically alters selection of functional T-cell subsets in A.CA transgenic mice

    Sho Ishikawa, Czeslawa Kowal, Betty Diamond in Immunogenetics (1993)