12 Result(s)

Article

Aphid cluster recognition and detection in the wild using deep learning models

Aphid infestation poses a significant threat to crop production, rural communities, and global food security. While chemical pest control is crucial for maximizing yields, applying chemicals across entire fiel...

Tianxiao Zhang, Kaidong Li, **angyu Chen, Cuncong Zhong, Bo Luo… in Scientific Reports (2023)

Article

Nano pom-poms prepared exosomes enable highly specific cancer biomarker detection

Extracellular vesicles (EVs), particularly nano-sized small EV exosomes, are emerging biomarker sources. However, due to heterogeneous populations secreted from diverse cell types, map** exosome multi-omic m...

Nan He, Sirisha Thippabhotla, Cuncong Zhong, Zachary Greenberg… in Communications Biology (2022)

Article

Prospective longitudinal study of kinetics of humoral response to one, two, or three doses of SARS-CoV-2 vaccine in hematopoietic cell transplant recipients

Qamar J. Khan, Cory R. Bivona, Ben Liu, Maggie Nelson… in Bone Marrow Transplantation (2022)

Article

Prospective correlation between the patient microbiome with response to and development of immune-mediated adverse effects to immunotherapy in lung cancer

Though the gut microbiome has been associated with efficacy of immunotherapy (ICI) in certain cancers, similar findings have not been identified for microbiomes from other body sites and their correlation to t...

Justin Chau, Meeta Yadav, Ben Liu, Muhammad Furqan, Qun Dai, Shailesh Shahi… in BMC Cancer (2021)

Article

Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis

Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and elevated cytoplasmic HuR correla...

**aoqing Wu, Gulhumay Gardashova, Lan Lan, Shuang Han… in Communications Biology (2020)

Article

3D cell culture stimulates the secretion of in vivo like extracellular vesicles

For studying cellular communications ex-vivo, a two-dimensional (2D) cell culture model is currently used as the “gold standard”. 2D culture models are also widely used in the study of RNA expression profiles fro...

Sirisha Thippabhotla, Cuncong Zhong, Mei He in Scientific Reports (2019)

Article

GRASP2: fast and memory-efficient gene-centric assembly and homolog search for metagenomic sequencing data

A crucial task in metagenomic analysis is to annotate the function and taxonomy of the sequencing reads generated from a microbiome sample. In general, the reads can either be assembled into contigs and search...

Cuncong Zhong, Youngik Yang, Shibu Yooseph in BMC Bioinformatics (2019)

Article

GRASPx: efficient homolog-search of short peptide metagenome database through simultaneous alignment and assembly

Metagenomics is a cultivation-independent approach that enables the study of the genomic composition of microbes present in an environment. Metagenomic samples are routinely sequenced using next-generation seq...

Cuncong Zhong, Youngik Yang, Shibu Yooseph in BMC Bioinformatics (2016)

Article

ProbeAlign: incorporating high-throughput sequencing-based structure probing information into ncRNA homology search

Recent advances in RNA structure probing technologies, including the ones based on high-throughput sequencing, have improved the accuracy of thermodynamic folding with quantitative nucleotide-resolution struct...

** Ge, Cuncong Zhong, Shaojie Zhang in BMC Bioinformatics (2014)

Article

Genome-wide methylated CpG island profiles of melanoma cells reveal a melanoma coregulation network

Metastatic melanoma is a malignant cancer with generally poor prognosis, with no targeted chemotherapy. To identify epigenetic changes related to melanoma, we have determined genome-wide methylated CpG island ...

Jian-Liang Li, Joseph Mazar, Cuncong Zhong, Geoffrey J. Faulkner… in Scientific Reports (2013)

Article

Efficient alignment of RNA secondary structures using sparse dynamic programming

Current advances of the next-generation sequencing technology have revealed a large number of un-annotated RNA transcripts. Comparative study of the RNA structurome is an important approach to assess their bio...

Cuncong Zhong, Shaojie Zhang in BMC Bioinformatics (2013)