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Open AccessProteomic and phosphoproteomic analyses of myectomy tissue reveals difference between sarcomeric and genotype-negative hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a genetically heterogenous condition with about half of cases remaining genetically elusive or non-genetic in origin. HCM patients with a positive genetic test (HCMSarc) prese...
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Vale Jean Garnier (1929–2022)
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A special issue of the Australian society for Biophysics
On behalf of the Australian Society for Biophysics (ASB) and the Editors of this Special Issue, I would like to express our appreciation to Editor-in-Chief, Damien Hall, for arranging the publication of this S...
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Open AccessPeripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease
In this review, we present our current understanding of peripartum cardiomyopathy (PPCM) based on reports of the incidence, diagnosis and current treatment options. We summarise opinions on whether PPCM is tri...
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Announcing the call for the Special Issue on “The Australian Society for Biophysics (ASB) – 2021 Meeting”
This Commentary describes a call for submissions for the upcoming Special Issue focused on the research topics presented at the Australian Society of Biophysics (ASB) in 2020 and 2021. Submissions from past an...
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Open AccessBlood-based protein profiling identifies serum protein c-KIT as a novel biomarker for hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is one of the most common hereditary heart diseases and can be classified into an obstructive (HOCM) and non-obstructive (HNCM) form. Major characteristics for HCM are the hyp...
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Open AccessNatural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy
Genetic variation is an important determinant of RNA transcription and splicing, which in turn contributes to variation in human traits, including cardiovascular diseases.
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Open AccessIntrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy
HCM, the most common inherited cardiac disease, is mainly caused by mutations in sarcomeric genes. More than a third of the patients are heterozygous for mutations in the MYH7 gene encoding for the β-myosin heavy...
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Special issue on titin and its binding proteins in striated muscle
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Limitations in Translating Animal Studies to Humans in Cardiovascular Disease
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Best practice BioBanking of human heart tissue
This review provides a guide to researchers who wish to establish a biobank. It also gives practical advice to investigators seeking access to samples of healthy or diseased human hearts. We begin with a brief...
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Manipulation of the Motility of Protein Molecular Motors on Microfabricated Substrates
Heavy meromyosin (HMM), a proteolytically cleaved derivative of myosin has previously been shown to interact with actin in well-established in vitro motility assays on nitrocellulose surfaces. In this study, t...