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Article
Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes
Four estrogen-functionalised copper complexes were synthesised and investigated as electrochemical active DNA binding and cleavage agents. These complexes strategically contain a biocompatible metal centre [Cu...
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Article
Open AccessTherapeutic potential of the phosphino Cu(I) complex (HydroCuP) in the treatment of solid tumors
[Cu(thp)4][PF6] (HydroCuP) is a phosphino copper(I) complex highly soluble and stable in physiological media that has been developed as a possible viable alternative to platinum-based drugs for anticancer therapy...
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Article
Predicting Dream Recall: EEG Activation During NREM Sleep or Shared Mechanisms with Wakefulness?
The common knowledge of a uniqueness of REM sleep as a privileged scenario of dreaming still persists, although consolidated empirical evidence shows that the assumption that dreaming is just an epiphenomenon of ...
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Article
Open AccessEpigenetic and antitumor effects of platinum(IV)-octanoato conjugates
We present the anticancer properties of cis, cis, trans-[Pt(IV)(NH3)2Cl2(OA)2] [Pt(IV)diOA] (OA = octanoato), Pt(IV) derivative of cisplatin containing two OA units appended to the axial positions of a six-coordi...
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Article
Open AccessOxidative Stress Induced by Pt(IV) Pro-drugs Based on the Cisplatin Scaffold and Indole Carboxylic Acids in Axial Position
The use of Pt(IV) complexes as pro-drugs that are activated by intracellular reduction is a widely investigated approach to overcome the limitations of Pt(II) anticancer agents. A series of ten mono- and bis-c...
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Article
Open AccessTargeting kinases with anilinopyrimidines: discovery of N-phenyl-N’-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily
Kinase inhibitors are attractive drugs/drug candidates for the treatment of cancer. The most recent literature has highlighted the importance of multi target kinase inhibitors, although a correct balance betwe...
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Chapter and Conference Paper
Synthesis, Characterization and Application of Iron Oxide Magnetic Nanoparticles for Magneto Fluid Hyperthermia Therapy
Magnetic Fluid Hyperthermia uses magnetic nanoparticle and time-varying magnetic field to heat tissue. A study on the correlation between synthetic parameters and morphological structure of magnetic iron nanop...
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Article
99mTc(N)-DBODC(5), a potential radiolabeled probe for SPECT of multidrug resistance: in vitro study
[99mTc(N)(DBODC)(PNP5)]+ [DBODC is bis(N-ethoxyethyl)dithiocarbamato; PNP5 is bis(dimethoxypropylphosphinoethyl)ethoxyethylamine], abbreviated as 99mTc(N)-DBODC(5), is a lipophilic cationic mixed compound investi...
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Article
Validity of the Italian Version of the Pittsburgh Sleep Quality Index (PSQI)
The aim of this study is to validate the Italian version of the Pittsburgh Sleep Quality Index (PSQI), comparing five different groups of individuals (healthy young and elderly, sleep apnoea syndrome patients,...
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Article
Cytotoxicity in human cancer cells and mitochondrial dysfunction induced by a series of new copper(I) complexes containing tris(2-cyanoethyl)phosphines
Over the last few years a lot of research has been done to develop novel metal-based anti-cancer drugs, with the aim of improving clinical effectiveness, reducing general toxicity, and broadening the spectrum ...
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Chapter
Synthesis of Cisplatin Analogues: Cytotoxic Efficacy and Anti-tumour Activity of Bis-Amidine and Bis-Iminoether Pt(II) Complexes
A series of new platinum(II) bis-amidine derivatives were prepared by addition of primary and secondary aliphatic amines to coordinated nitrile ligands in cis- and trans-[PtCl2(NCR)2] (R=Me, Ph, CH2Ph). The bis-a...
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Article
Can an inert slee** pill affect sleep? Effects on polysomnographic, behavioral and subjective measures
Since two recent meta-analyses on sleep changes associated with placebo in clinical trials suggested a beneficial effect of placebo treatments, pointing to a dissociation between subjective and objective measu...
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Article
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