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Article
Open AccessAlternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction
Force transmission through adherens junctions (AJs) is crucial for multicellular organization, wound healing and tissue regeneration. Recent studies shed light on the molecular mechanisms of mechanotransductio...
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Article
Community-developed checklists for publishing images and image analyses
Images document scientific discoveries and are prevalent in modern biomedical research. Microscopy imaging in particular is currently undergoing rapid technological advancements. However, for scientists wishin...
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Article
Open AccessVolumePeeler: a novel FIJI plugin for geometric tissue peeling to improve visualization and quantification of 3D image stacks
Quantitative descriptions of multi-cellular structures from optical microscopy imaging are prime to understand the variety of three-dimensional (3D) shapes in living organisms. Experimental models of vertebrat...
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Article
Open AccessPalmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism
Palmitic acid (PA) is significantly increased in the hypothalamus of mice, when fed chronically with a high-fat diet (HFD). PA impairs insulin signaling in hypothalamic neurons, by a mechanism dependent on aut...
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Article
Open AccessAuthor Correction: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessAuthor Correction: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessSingle-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity
The Eph family of receptor tyrosine kinases is crucial for assembly and maintenance of healthy tissues. Dysfunction in Eph signaling is causally associated with cancer progression. In breast cancer cells, dysr...
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Article
Nanoscale architecture of cadherin-based cell adhesions
Multicellularity in animals requires dynamic maintenance of cell–cell contacts. Intercellularly ligated cadherins recruit numerous proteins to form supramolecular complexes that connect with the actin cytoskel...
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Article
Open AccessGap geometry dictates epithelial closure efficiency
Closure of wounds and gaps in tissues is fundamental for the correct development and physiology of multicellular organisms and, when misregulated, may lead to inflammation and tumorigenesis. To re-establish ti...
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Article
Open AccessLevosimendan inhibits release of reactive oxygen species in polymorphonuclear leukocytes in vitro and in patients with acute heart failure and septic shock: a prospective observational study
Levosimendan is an extensively investigated inodilator showing also cardioprotective and antiinflammatory effects. The aim of our study was to explore the influence of levosimendan on polymorphonuclear leucocy...
