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Article

Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival

TBC1D10C is a protein previously demonstrated to bind and inhibit Ras and Calcineurin. In cardiomyocytes, also CaMKII is inhibited and all three targeted enzymes are known to promote maladaptive cardiomyocyte ...

Cornelia Volland, Sebastian Bremer, Kristian Hellenkamp… in Scientific Reports (2016)